Mitochondrial serine hydroxymethyltransferase 2 is a potential diagnostic and prognostic biomarker for human glioma.

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Abstract

Scholars have gradually come to appreciate the relevance of serine and glycine metabolism. Recently, researchers have discovered that mitochondrial serine hydroxymethyltransferase 2 (SHMT2) is overexpressed in various types of cancer. However, the function of SHMT2 in glioma is not clear. In this study, we sought to examine the expression of SHMT2 in glioma, the association between SHMT2 expression and clinicopathological characteristics, and the association of SHMT2 expression with prognosis in glioma patients.

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Journal

Journal ID (iso-abbrev): Clin Neurol Neurosurg

Title: Clinical neurology and neurosurgery

Publisher: Elsevier BV

ISSN (Electronic): 1872-6968

ISSN (Print): 0303-8467

Publication date (Electronic): Mar 2017

Volume: 154

Affiliations

[1 ] Department of Neurosurgery, Tianjin HuanHu Hospital, Tianjin Key Laboratory of Cerebrovascular Disease and Neurodegenerative Disease, Tianjin Neurosurgical Institute, 6 Jizhao Road, Tianjin, China.

[2 ] Department of Rehabilitation, Tianjin HuanHu Hospital, 6 Jizhao Road, Tianjin, China.

[3 ] Department of Pathology, Tianjin HuanHu Hospital, 6 Jizhao Road, Tianjin, China.

[4 ] Department of Neurosurgery, Tianjin Medical University, General Hospital, Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin Neurological Institute, 154 Anshan Road, Tianjin, China.

[5 ] Department of Gastroenterology, Tianjin NanKai Hospital, 6 Changjiang Road, Tianjin, China.

[6 ] Department of Pathology, Tianjin HuanHu Hospital, 6 Jizhao Road, Tianjin, China. Electronic address: submissionpaper@sina.com.

[7 ] Department of Hepatic Biliary Pancreatic Surgery, Cancer Hospital Affiliated to Zhengzhou University, 127 Dongming Road, Zhengzhou, Henan Province, China.

Article

Publisher Item ID: S0303-8467(17)30005-7

DOI: 10.1016/j.clineuro.2017.01.005

PubMed ID: 28107674

SO-VID: 20b4b4b0-bcc4-48c6-95b5-9cbe6ab485fd

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Keywords: Glioma,Mitochondrial serine hydroxymethyltransferase 2 (SHMT2),Oncology,Prognosis

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Keywords: Glioma, Mitochondrial serine hydroxymethyltransferase 2 (SHMT2), Oncology, Prognosis

Mitochondrial serine hydroxymethyltransferase 2 is a potential diagnostic and prognostic biomarker for human glioma.

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Karger: Oncology

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