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      Dual targeting of SREBP2 and ERRα by carnosic acid suppresses RANKL-mediated osteoclastogenesis and prevents ovariectomy-induced bone loss

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          Most cited references 51

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          Multilineage Potential of Adult Human Mesenchymal Stem Cells

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            Mechanisms of bone metastasis.

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              Skeletal remodeling in health and disease.

               Mone Zaidi (2007)
              The use of genetically manipulated mouse models, gene and protein discovery and the cataloguing of genetic mutations have each allowed us to obtain new insights into skeletal morphogenesis and remodeling. These techniques have made it possible to identify molecules that are obligatory for specific cellular functions, and to exploit these molecules for therapeutic purposes. New insights into the pathophysiology of diseases have also enabled us to understand molecular defects in a way that was not possible a decade ago. This review summarizes our current understanding of the carefully orchestrated cross-talk between cells of the bone marrow and between bone cells and the brain through which bone is constantly remodeled during adult life. It also highlights molecular aberrations that cause bone cells to become dysfunctional, as well as therapeutic options and opportunities to counteract skeletal loss.
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                Author and article information

                Journal
                Cell Death & Differentiation
                Cell Death Differ
                Springer Science and Business Media LLC
                1350-9047
                1476-5403
                January 6 2020
                Article
                10.1038/s41418-019-0484-5
                © 2020

                http://www.springer.com/tdm

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