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      Searching and Navigating UniProt Databases.

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          Abstract

          The Universal Protein Resource (UniProt) is a comprehensive resource for protein sequence and annotation data. The UniProt Web site receives ∼400,000 unique visitors per month and is the primary means to access UniProt. It provides ten searchable datasets and three main tools. The key UniProt datasets are the UniProt Knowledgebase (UniProtKB), the UniProt Reference Clusters (UniRef), the UniProt Archive (UniParc), and protein sets for completely sequenced genomes (Proteomes). Other supporting datasets include information about proteins that is present in UniProtKB protein entries such as literature citations, taxonomy, and subcellular locations, among others. This paper focuses on how to use UniProt datasets. The basic protocol describes navigation and searching mechanisms for the UniProt datasets, while two alternative protocols build on the basic protocol to describe advanced search and query building.

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          Author and article information

          Journal
          Curr Protoc Bioinformatics
          Current protocols in bioinformatics
          1934-340X
          1934-3396
          Jun 19 2015
          : 50
          Affiliations
          [1 ] European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge, United Kingdom.
          Article
          NIHMS703123
          10.1002/0471250953.bi0127s50
          4522465
          26088053
          21830e1a-4449-4ca3-a9e2-1eb8091e6c3e
          Copyright © 2015 John Wiley & Sons, Inc.

          UniProt,navigation,search,tutorial
          UniProt, navigation, search, tutorial

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