Understanding Mechanisms of Resistance in Metastatic Castration-resistant Prostate Cancer: The Role of the Androgen Receptor.

Tilki, Derya; Schaeffer, Edward M.; Evans, Christopher P.

doi:10.1016/j.euf.2016.11.013

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Understanding Mechanisms of Resistance in Metastatic Castration-resistant Prostate Cancer: The Role of the Androgen Receptor.

Author(s): Derya Tilki ¹ , Edward M Schaeffer ² , Christopher P Evans ³

Publication date (Electronic): Dec 2016

Journal: European urology focus

Publisher: Elsevier BV

Keywords: Androgen receptor, Castration-resistant prostate cancer, Mechanisms, Metastasis, Review

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Abstract

After initiation of androgen deprivation therapy (ADT), most patients progress to castration-resistant prostate cancer (CRPC) within 2 or 3 yr. In the USA, approximately 67000 men are estimated to have metastatic CRPC.

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Journal ID (iso-abbrev): Eur Urol Focus

Title: European urology focus

Publisher: Elsevier BV

ISSN (Electronic): 2405-4569

ISSN (Print): 2405-4569

Publication date (Electronic): Dec 2016

Volume: 2

Issue: 5

Affiliations

[1 ] Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, Hamburg, Germany; Department of Urology, University Hospital Hamburg-Eppendorf, Hamburg, Germany. Electronic address: d.tilki@uke.de.

[2 ] Department of Urology, Northwestern Medicine, Chicago, IL, USA.

[3 ] Department of Urology, School of Medicine, University of California-Davis, Sacramento, CA, USA.

Article

Publisher Item ID: S2405-4569(16)30171-7

DOI: 10.1016/j.euf.2016.11.013

PubMed ID: 28723515

SO-VID: 21976c0e-43eb-40ec-ac6b-d7f0b79f029b

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Keywords: Androgen receptor,Mechanisms,Metastasis,Review,Castration-resistant prostate cancer

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Keywords: Androgen receptor, Mechanisms, Metastasis, Review, Castration-resistant prostate cancer

Understanding Mechanisms of Resistance in Metastatic Castration-resistant Prostate Cancer: The Role of the Androgen Receptor.

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