FBXO31 sensitizes cancer stem cells-like cells to cisplatin by promoting ferroptosis and facilitating proteasomal degradation of GPX4 in cholangiocarcinoma.

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Abstract

Cholangiocarcinoma (CCA) is a malignant tumour originating from the biliary epithelium that easily infiltrates, metastasizes and recurs. The deficiency of FBXO31 facilitates the initiation and progression of several types of cancer. However, the involvement of FBXO31 in CCA progression has remained unclear.

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Journal

Journal ID (iso-abbrev): Liver Int

Title: Liver international : official journal of the International Association for the Study of the Liver

Publisher: Wiley

ISSN (Electronic): 1478-3231

ISSN (Print): 1478-3223

Publication date (Electronic): Dec 2022

Volume: 42

Issue: 12

Affiliations

[1 ] Department of Hepatobiliary Surgery, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.

[2 ] Clinical Research Center, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.

[3 ] Institution of Plastic Surgery, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.

Article

DOI: 10.1111/liv.15462

PubMed ID: 36269678

SO-VID: 22ce8267-1be9-4b9e-96e1-0f6dbc4a34d1

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