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      Evaluation of remodeling and regeneration of electrospun PCL/fibrin vascular grafts in vivo


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          The success of artificial vascular graft in the host to obtain functional tissue regeneration and remodeling is a great challenge in the field of small diameter tissue engineering blood vessels. In our previous work, poly(ε-caprolactone) (PCL)/fibrin vascular grafts were fabricated by electrospinning. It was proved that the PCL/fibrin vascular graft was a suitable small diameter tissue engineering vascular scaffold with good biomechanical properties and cell compatibility. Here we mainly examined the performance of PCL/fibrin vascular graft in vivo. The graft showed randomly arranged nanofiber structure, excellent mechanical strength, higher compliance and degradation properties. At 9 months after implantation in the rat abdominal aorta, the graft induced the regeneration of neoarteries, and promoted ECM deposition and rapid endothelialization. More importantly, the PCL/fibrin vascular graft showed more microvessels density and fewer calcification areas at 3 months, which was beneficial to improve cell infiltration and proliferation. Moreover, the ratio of M2/M1macrophage in PCL/fibrin graft had a higher expression level and the secretion amount of pro-inflammatory cytokines started to increase, and then decreased to similar to the native artery. Thus, the electrospun PCL/fibrin tubular vascular graft had great potential to become a new type of artificial blood vessel scaffold that can be implanted in vivo for long term.

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          Author and article information

          Mater Sci Eng C Mater Biol Appl
          Mater Sci Eng C Mater Biol Appl
          Materials Science & Engineering. C, Materials for Biological Applications
          Published by Elsevier B.V.
          25 August 2020
          25 August 2020
          : 111441
          [a ]College of Life Science and Technology, Xinxiang Medical University, Xinxiang, China
          [b ]Key Laboratory of Cardiac Structure Research, Zhengzhou Seventh People's Hospital, Zhengzhou, China
          [c ]College of Medical Engineering, Xinxiang Medical University, Xinxiang, China
          [d ]First Affiliated Hospital, Xinxiang Medical University, Xinxiang, China
          [e ]Nursing school, Xinxiang Medical University, Xinxiang, China
          [f ]The First Affiliated Hospital, Henan University of Science and Technology, Luoyang, China
          [g ]Service Center for Transformation of Scientific and Technological Achievements, Xinxiang Medical University, Xinxiang, China
          [h ]General Surgery Department, West District Hospital of Nanyang The First People's Hospital, Nanyang, China
          Author notes
          [* ]Correspondence to: Liang Zhao, Key Laboratory of Cardiac Structure Research, Zhengzhou Seventh People's Hospital, Zhengzhou, China. zhaoliang4321@ 123456163.com

          These authors contributed equally to this work.

          S0928-4931(20)33359-2 111441
          © 2020 Published by Elsevier B.V.

          Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

          : 22 April 2020
          : 16 August 2020
          : 21 August 2020

          pcl/fibrin vascular grafts,electrospinning,tissue remodeling and regeneration,in vivo,inflammatory cytokines


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