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      Paradoxical Growth Hormone Response following Thyroid-Stimulating Hormone Administration in the Polycystic Ovary Syndrome

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          Abstract

          Growth hormone (GH) and prolactin (PRL) responses after TRH administration were studied in 31 women presenting with the clinical, biochemical and ultrasonographic characteristics of the polycystic ovarian (PCO) syndrome; their results were compared with those of 20 normally menstruating women investigated during the early follicular phase of the cycle. Based on the GH responses two PCO subgroups were observed: (a) nonresponders (n = 16) who showed △max GH responses (0.7 ± 0.27 ng/ml, x ± SE) similar to those of the normals (0.97 ± 0.20 ng/ml), and (b) responders (n = 15), 48.4% of the PCO patients who showed a paradoxical increase in GH levels (△max GH, 18.0 ± 1.96 ng/ml) following thyrotropin-releasing hormone (TRH) administration significantly higher than those observed either in nonresponder PCO patients or in normals. Furthermore, basal GH levels were found to be significantly higher in the responder PCO subgroup (5.65 ± 0.75 ng/ml) compared to either nonresponders (1.58 ± 0.21 ng/ml) or normals (1.8 ± 0.18 ng/ml). However, no correlation was found between basal GH levels and △max GH responses observed. Additionally, basal PRL and △max PRL levels following TRH administration did not differ either between the two PCO subgroups or those observed in normal controls. Δ<sub>4</sub>A, T and E<sub>2</sub> levels were similar between the two PCO subgroups. No correlation was found between the △max GH responses to △max PRL or the post-luteinizing hormone-releasing hormone stimulation test △max luteinizing hormone:follicle-stimulating hormone ratio observed or to steroid levels. These data are suggestive of an abnormal responsiveness of somatotrophs to TRH stimulation in 48.4% of PCO patients which could not be correlated either with an abnormality of lactotrophs or with a difference of the androgen and E<sub>2</sub> levels.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1989
          1989
          02 December 2008
          : 31
          : 3
          : 119-124
          Affiliations
          Endocrine Unit of the Department of Pathologic Physiology, General ‘Laikon’ Hospital, Medical School of the University of Athens, Greece
          Article
          181100 Horm Res 1989;31:119–124
          10.1159/000181100
          2501207
          © 1989 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          Original Paper

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