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      Successful Culotte Stenting for Unprotected Left Main Trifurcation Disease: Insights from Optical Coherence Tomography

      case-report
      , MD 1 , , MD, PhD 2 , , , MD, PhD 2 , , MD, PhD 2 , , MD, PhD 1 , , MD, PhD 1 , , MD, PhD 2 , , MD, PhD 2
      Korean Circulation Journal
      The Korean Society of Cardiology

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          Abstract

          A 41-year-old man presenting with new-onset effort angina was referred to our clinic. Angiography revealed a left main trifurcation lesion including significant stenosis in the unprotected left main coronary artery (ULMCA), ostial left anterior descending artery (LAD), ostial left circumflex artery (LCX) with grade 3 collateral flow from the right coronary artery, and diffuse ramus intermedius artery (RI) (Supplementary Video 1). After an 8-French extra backup guiding catheter with a side hole was engaged into the left coronary artery via the right femoral approach, plain old balloon angioplasty (POBA) was performed from the ULMCA to LAD, LCX, and RI, respectively. Optical coherence tomography (OCT) demonstrated successful POBA for ostial LCX; thus, percutaneous coronary intervention (PCI) was planned with the 2-stent culotte technique from the ULMCA to the LAD and RI, rather than the crush technique, because 3 strut layers should be avoided on the ostial LCX (Figure 1A). A 3.0×38 mm everolimus-eluting stent (EES; Xience Sierra®, Abbott Vascular) was implanted from the ULMCA to the RI. Subsequently, a 3.5×18 mm EES implantation from the ULMCA to the LAD was achieved with the culotte technique. After stent optimization with kissing balloon inflation and the proximal optimization technique, the final angiography showed no residual stenosis (Figure 1B and Supplementary Video 2), and post-stenting OCT demonstrated a minimized neo-carina between the ostial LAD and RI (Figure 1C) and two strut layers from the distal left main trunk to the shaft including the ostial LCX (Figure 1D-J). The high resolution (10 µm) of OCT can provide detailed post-PCI information, including stent apposition and edge dissections, but there are limited data regarding the OCT-guided PCI with two-stent technique for the bifurcation lesion, especially ULMCA.1) 2) This case highlights the feasibility of OCT-guided complex PCI and OCT images of successful culotte technique.

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          Optimization of Percutaneous Coronary Intervention Using Optical Coherence Tomography

          Compared to the luminogram obtained by angiography, intravascular modalities produce cross-sectional images of coronary arteries with a far greater spatial resolution. It is capable of accurately determining the vessel size and plaque morphology. It also eliminates some disadvantages such as contrast streaming, foreshortening, vessel overlap, and angle dependency inherent to angiography. Currently, the development of its system and the visualization of coronary arteries has shown significant advancement. Of those, optical coherence tomography (OCT) makes it possible to obtain high-resolution images of intraluminal and transmural coronary structures leading to navigation of the treatment strategy before and after stent implantations. The aim of this review is to summarize the published data on the clinical utility of OCT, focusing on the use of OCT in interventional cardiology practice to optimize percutaneous coronary intervention.
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            Optical Coherence Tomography Findings of Non-ST Elevation Myocardial Infarction with Multivessel Disease

            A 48-year-old man with a history of current smoking presented to our department with sudden-onset chest pain at rest. Elevated high sensitivity troponin level led to urgent coronary angiography (CAG). CAG revealed intermediate stenosis with multiple linear filling defects in the mid right coronary artery (RCA) (Figure 1A). Cross-sectional (Figure 1B-1D) and longitudinal (Figure 1F) optical coherence tomography (OCT) demonstrated a honeycomb-like structure with multiple cavities of various size separated by tissue with high-signal intensity (Supplementary Video 1). Three-dimensional OCT also showed multiple cavities communicating with true lumen (Figure 1E, asterisks) and we concluded that this represented recanalized thrombus. Regarding the left anterior descending artery (LAD) lesion, CAG revealed severe stenosis in the proximal LAD (Figure 1G). OCT demonstrated thrombus, both protruding (Figure 1K, arrow) and laminar (Figure 1H, 1I, and 1L, arrowheads) with underlying heterogenous plaque without evidence of disruption, suggestive of plaque erosion, and minimal lumen area of 2.24 mm2 (Figure 1J) (Supplementary Video 2). Therefore, based on OCT findings, we concluded that the proximal LAD was more relevant to the culprit lesion. Successful percutaneous coronary intervention was achieved with a 3.5×32 mm novolimus-eluting stent in the RCA and 4.0×23 mm everolimus-eluting stent in the LAD. CAG in patients presenting with non-ST elevation acute coronary syndrome can pose diagnostic challenges (>10% patients have multiple culprits and >30% no identifiable culprit).1) We report the invaluable role that intracoronary imaging can play in delineating the underlying substrate for acute coronary syndrome, as highlighted in the recent expert consensus. 2)
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              Author and article information

              Journal
              Korean Circ J
              Korean Circ J
              KCJ
              Korean Circulation Journal
              The Korean Society of Cardiology
              1738-5520
              1738-5555
              August 2020
              20 March 2020
              : 50
              : 8
              : 740-742
              Affiliations
              [1 ]Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine and Cardiovascular Center, Yongin Severance Hospital, Yongin, Korea.
              [2 ]Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.
              Author notes
              Correspondence to Byeong-Keuk Kim, MD, PhD. Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, 250 Seongsan-ro, Seodaemun-gu, Seoul 03722, Korea. kimbk@ 123456yuhs.ac
              Author information
              https://orcid.org/0000-0001-5568-4161
              https://orcid.org/0000-0003-2493-066X
              https://orcid.org/0000-0003-4893-039X
              https://orcid.org/0000-0003-2263-3274
              https://orcid.org/0000-0002-3881-411X
              https://orcid.org/0000-0002-2009-9760
              https://orcid.org/0000-0002-2090-2031
              https://orcid.org/0000-0002-2169-3112
              Article
              10.4070/kcj.2020.0026
              7390721
              32725982
              238dc66c-3f1b-40a5-9b83-e558170cee24
              Copyright © 2020. The Korean Society of Cardiology

              This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

              History
              : 20 January 2020
              : 19 February 2020
              : 11 March 2020
              Categories
              Images in Cardiovascular Medicine

              Cardiovascular Medicine
              Cardiovascular Medicine

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