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      Life-Threatening Thyrotoxicosis: Thyroid Storm

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      Endocrinology and Metabolism Clinics of North America
      Elsevier BV

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          Abstract

          Although important strides in recognition and therapy have significantly reduced the mortality in this disorder from the nearly 100% fatality rate noted by Lahey, survival is by no means guaranteed. More recent series have yielded fatality rates between 20% and 50%. Although some authors have attributed this improvement, in part, to a relaxation of the diagnostic criteria for thyroid storm, it more likely represents improvements in early recognition and the beneficial effects of the serial addition of antithyroid, corticosteroid, and antiadrenergic therapies to the treatment of this disorder. Thyroid storm is a dreaded, fortunately rare complication of a very common disorder. Most cases of thyroid storm occur following a precipitating event or intercurrent illness. Effective management is predicated on a prompt recognition of impending thyroid storm which is, in turn, dependent on a thorough knowledge of both the typical and atypical presentations of this disorder. An unwavering commitment to an aggressive, multifaceted therapeutic intervention as outlined herein is critical to the obtainment of a satisfactory outcome.

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          Author and article information

          Journal
          Endocrinology and Metabolism Clinics of North America
          Endocrinology and Metabolism Clinics of North America
          Elsevier BV
          08898529
          June 1993
          June 1993
          : 22
          : 2
          : 263-277
          Article
          10.1016/S0889-8529(18)30165-8
          8325286
          24d9303a-e7db-474a-9554-3c02cd7de250
          © 1993

          https://www.elsevier.com/tdm/userlicense/1.0/

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