Domino N-/C-Arylation via In Situ Generation of a Directing Group: Atom-Efficient Arylation Using Diaryliodonium Salts.

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Abstract

Both aryl components of diaryliodonium salts can be used in a domino one-pot reaction via in situ generation of a directing group. A number of heterocycles undergo N-arylation which is followed by ruthenium-catalyzed C-arylation. Notably the reaction extends well to unsymmetrical diaryliodonium salts with a number of highly selective examples shown.

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Journal

Journal ID (iso-abbrev): Angew. Chem. Int. Ed. Engl.

Title: Angewandte Chemie (International ed. in English)

Publisher: Wiley-Blackwell

ISSN (Electronic): 1521-3773

ISSN (Print): 1433-7851

Publication date (Electronic): May 02 2017

Volume: 56

Issue: 19

Affiliations

[1 ] School of Chemistry, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK.

Article

DOI: 10.1002/anie.201701523

PubMed ID: 28387054

SO-VID: 25a72929-71a5-4166-aa72-6f03d2d75479

History

Keywords: C-H activation,N-heterocycles,arylation,iodonium compounds

Data availability:

Keywords: C-H activation, N-heterocycles, arylation, iodonium compounds

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