Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
29
April
2016
Publication date Collection: 2016
Volume: 11
Issue: 4
Electronic Location Identifier: e0154437
Affiliations
[1
]Department of Ophthalmology and Visual Sciences, University of Maryland School of
Medicine, Baltimore, MD, 21201, United States of America
[2
]Center for Nanomedicine, Department of Ophthalmology, Wilmer Eye Institute, Johns
Hopkins School of Medicine, Baltimore, MD, 21287, United States of America
[3
]Division of Neuro-Ophthalmology, Department of Ophthalmology, Wilmer Eye Institute,
Johns Hopkins School of Medicine, Baltimore, MD, 21287, United States of America
[4
]Department of Anatomy and Neurobiology, University of Maryland School of Medicine,
Baltimore, MD, 21201, United States of America
Hanson Institute, AUSTRALIA
Author notes
Competing Interests: The dendrimer technology utilized in this manuscript is protected by awarded and pending
patents, listed below. Dr. Kannan Rangaramanujam is co-inventor on these patents,
and is a co-founder and chief technology officer of two companies, Ashvattha Therapeutics,
LLC and Orpheris Inc., that are commercializing this technology. This does not alter
the authors’ adherence to PLOS ONE policies on sharing data and materials. (1) Dendrimer-containing
particles for sustained release of compounds, Kannan RM, Iezzi R, Kannan S, US provisional
patent filed 10/5/07, Regular patents filed in US (#12/681,516, pending), Canada (#2,701,291),
European Union (#08835693.6), Japan (#2010-528216, awarded) and India (1247/ELNP/2010)
(Apr. 2010). Japanese Patent Awarded. (2) Dendrimer-based therapeutic nanodevices
for therapeutic and imaging applications, Kannan RM, Kannan S, Romero R, Navath R,
Dai H, Kurtoglu Y, Wang B, Menjoge A, Provisional patent filed # 61/187263, 5/09,
US patent (#12/797,657, awarded 2014). (3) Novel Drug Delivery Systems for Systemic
Therapies for Back of the Eye Diseases, Kannan RM, Lutty G, Kambhampati S, Mishra
M, Bhutto I, US Provisional Patent, #61/986,495, Provisional PCT Application No. US2015/028386.
Conceived and designed the experiments: SLB NRM MAJ RK. Performed the experiments:
YG ZM. Analyzed the data: SLB NRM MAJ YG ZM RK. Contributed reagents/materials/analysis
tools: MKM RK. Wrote the paper: SLB NRM MAJ RK ZM YG.
Article
Publisher ID:
PONE-D-16-03142
DOI: 10.1371/journal.pone.0154437
PMC ID: 4851377
PubMed ID: 27128315
SO-VID: 265e3b4f-b846-4d37-aa43-d236496b54f4
Copyright © © 2016 Guo et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: funder-id http://dx.doi.org/10.13039/100000053, National Eye Institute;
Award ID: EY105304
Award Recipient
:
Steven L. Bernstein
Funded by: funder-id http://dx.doi.org/10.13039/100000053, National Eye Institute;
Award ID: EY019529
Award Recipient
:
Steven L. Bernstein
Funded by: Johns Hopkins University Fund
Award Recipient
:
Neil R. Miller
Funded by: funder-id http://dx.doi.org/10.13039/100000070, National Institute of Biomedical Imaging and Bioengineering;
Award ID: EB018306
Award Recipient
:
Rangaramanujam Kannan
This work was funded by NEI RO1EY01530 and RO1EY019529 to SLB, RO1EY025304 to RK (
https://nei.nih.gov), NIBIB RO1 EB018306 to RK (
http://www.nibib.nih.gov), and Johns Hopkins Optic Nerve Research Fund to NRM.
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Head
Subject:
Eyes
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Head
Subject:
Eyes
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Ocular System
Subject:
Eyes
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Ocular System
Subject:
Eyes
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Glial Cells
Subject:
Macroglial Cells
Subject:
Astrocytes
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Response
Subject:
Inflammation
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Response
Subject:
Inflammation
Subject:
Medicine and Health Sciences
Subject:
Diagnostic Medicine
Subject:
Signs and Symptoms
Subject:
Inflammation
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Signs and Symptoms
Subject:
Inflammation
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Ocular System
Subject:
Ocular Anatomy
Subject:
Retina
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Ocular System
Subject:
Ocular Anatomy
Subject:
Retina
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Ocular System
Subject:
Optic Nerve
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Ocular System
Subject:
Optic Nerve
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Blood Cells
Subject:
White Blood Cells
Subject:
Macrophages
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
Macrophages
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
Macrophages
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
Macrophages
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Animals
Subject:
Vertebrates
Subject:
Amniotes
Subject:
Mammals
Subject:
Primates
Subject:
Medicine and Health Sciences
Subject:
Vascular Medicine
Subject:
Ischemia
