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      Influence of Progesterone/Estradiol Ratio on Luteal Function for Achieving Pregnancy in Gonadotropin Therapy

      , ,

      Hormone Research in Paediatrics

      S. Karger AG

      Progesterone/estradiol ratio, Luteal function, Gonadotropin therapy

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          Abstract

          The purpose of this study was to evaluate the influence of the relationship between plasma progesterone (P<sub>4</sub>) and estradiol (E<sub>2</sub>) levels in the luteal phase for achieving pregnancy in human menopausal gonadotropin (hMG)-human chorionic gonadotropin (hCG)-treated cycles. Plasma P<sub>4</sub> and E<sub>2</sub> levels were determined in 93 hMG-hCG-treated cycles (23 pregnant and 70 nonpregnant) of 46 patients during 3 periods of the luteal phase, using radioimmunoassay. In addition, 88 spontaneous ovulatory cycles and 100 clomiphene-treated cycles were also studied in the same manner. In hMG-hCG-treated cycles in the early luteal phase, the P<sub>4</sub>/E<sub>2</sub> ratio in pregnant cycles was significantly higher than that in nonpregnant cycles. There was no significant difference between the P<sub>4</sub>/E<sub>2 </sub>ratios of the luteal phase of hMG-hCG-treated pregnant-group, clomiphene-treated and spontaneous ovulatory cycles. In nonpregnant cycles, however, the P<sub>4</sub>/E<sub>2</sub> ratio in hMG-hCG-treated cycles was significantly lower than that in clomiphene-treated or spontaneous ovulatory cycles. These results suggest that in hMG-hCG-treated cycles, the P<sub>4</sub>/E<sub>2</sub> ratio may be a more reliable index of luteal function for achieving pregnancy than P<sub>4</sub> levels alone.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          978-3-8055-5625-5
          978-3-318-01972-8
          1663-2818
          1663-2826
          1992
          1992
          03 December 2008
          : 37
          : Suppl 1
          : 59-63
          Affiliations
          Department of Obstetrics and Gynecology, Faculty of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
          Article
          182353 Horm Res 1992;37:59–63
          10.1159/000182353
          1427631
          © 1992 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          New Aspects of the Physiology and Pathology of the Luteal Phase

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