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      Influence of Progesterone/Estradiol Ratio on Luteal Function for Achieving Pregnancy in Gonadotropin Therapy

      , ,

      Hormone Research in Paediatrics

      S. Karger AG

      Progesterone/estradiol ratio, Luteal function, Gonadotropin therapy

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          The purpose of this study was to evaluate the influence of the relationship between plasma progesterone (P<sub>4</sub>) and estradiol (E<sub>2</sub>) levels in the luteal phase for achieving pregnancy in human menopausal gonadotropin (hMG)-human chorionic gonadotropin (hCG)-treated cycles. Plasma P<sub>4</sub> and E<sub>2</sub> levels were determined in 93 hMG-hCG-treated cycles (23 pregnant and 70 nonpregnant) of 46 patients during 3 periods of the luteal phase, using radioimmunoassay. In addition, 88 spontaneous ovulatory cycles and 100 clomiphene-treated cycles were also studied in the same manner. In hMG-hCG-treated cycles in the early luteal phase, the P<sub>4</sub>/E<sub>2</sub> ratio in pregnant cycles was significantly higher than that in nonpregnant cycles. There was no significant difference between the P<sub>4</sub>/E<sub>2 </sub>ratios of the luteal phase of hMG-hCG-treated pregnant-group, clomiphene-treated and spontaneous ovulatory cycles. In nonpregnant cycles, however, the P<sub>4</sub>/E<sub>2</sub> ratio in hMG-hCG-treated cycles was significantly lower than that in clomiphene-treated or spontaneous ovulatory cycles. These results suggest that in hMG-hCG-treated cycles, the P<sub>4</sub>/E<sub>2</sub> ratio may be a more reliable index of luteal function for achieving pregnancy than P<sub>4</sub> levels alone.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          03 December 2008
          : 37
          : Suppl 1
          : 59-63
          Department of Obstetrics and Gynecology, Faculty of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
          182353 Horm Res 1992;37:59–63
          © 1992 S. Karger AG, Basel

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          Page count
          Pages: 5
          New Aspects of the Physiology and Pathology of the Luteal Phase


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