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      Pulsed EMF stimulation increased BDNF and activated S6 levels in the hippocampus of senescent rats

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          Abstract

          Purpose

          Low-frequency electromagnetic field (EMF) exposure in rat has positive effects on neuronal processes in vitro. Moreover, EMF improves learning-memory and psychomotor activity during advanced ageing, but the underlying molecular mechanisms are not known in the brain. In the present study we aimed to investigate the molecular effects of chronic EMF stimulation in the hippocampus of senescent rats in vivo.

          Materials/Methods

          Thirty months old rats were treated for six weeks with different EMF doses of 45, 95, and 1,250 µT. After sacrifice the levels of Brain Derived Neurotrophic Factor (BDNF) and activated ribosomal protein S6 as measures for protein synthesis intensity in the hippocampus were determined by Western blot analysis.

          Results

          The results showed that chronic EMF exposure dose dependently increased BDNF and the amount of phosphorylated S6 protein at the highest dose. The effects on the two proteins positively correlated at individual level. The results indicate that EMF exposure may enhance neurotrophic processes indicated by increased BDNF expression in the hippocampus of senescent rats. Increased phosphorylated S6 protein suggests coupling to support molecular regulation of protein synthesis.

          Conclusions

          In a broader perspective, these findings may support EMF as a beneficial alternative form of passive exercise in active, exercise-limited, aged individuals.

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          Author and article information

          Contributors
          Journal
          2066
          Developments in Health Sciences
          DHS
          Akadémiai Kiadó (Budapest )
          2630-9378
          2630-936X
          20 October 2021
          10 February 2022
          : 4
          : 1
          : 7-10
          Affiliations
          [1 ] Department of Morphology and Physiology, Faculty of Health Sciences, Semmelweis University , Budapest, Hungary
          [2 ] Research Center for Molecular Exercise Science, University of Physical Education , Budapest, Hungary
          [3 ] Groningen Institute for Evolutionary Life Sciences (GELIFES), Department of Molecular Neurobiology, University of Groningen , Groningen, The Netherlands
          Author notes
          [* ]Corresponding author. Department of Morphology and Physiology, Faculty of Health Sciences, Semmelweis University , H–1088, Vas u. 17, Budapest, Hungary. E-mail: nyakas.csaba@ 123456se-etk.hu
          Article
          10.1556/2066.2021.00043
          27dd196c-9f88-4bbd-a09b-039ea1e7d8f4
          © 2021 The Author(s)

          Open Access. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited, a link to the CC License is provided, and changes – if any – are indicated. (SID_1)

          Page count
          Figures: 2, Equations: 0, References: 18, Pages: 04
          Funding
          Funded by: Semmelweis University
          Funded by: National Bionics Program
          Award ID: ED_17-1-2017-0009
          Custom metadata
          1

          Medicine,Immunology,Health & Social care,Microbiology & Virology,Infectious disease & Microbiology
          S6,hippocampus,senescent age,BDNF,EMF stimulation

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