0
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Hormone Excretion in Pregnancy Following Gonadotrophin Treatment

      Read this article at

      ScienceOpenPublisher
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          40 consecutive pregnancies following treatment of infertile women with gonadotrophins were investigated. The 24-hourly excretion of oestriol, pregnanediol and chorionic gonadotrophin was measured at weekly intervals and correlated with the clinical findings. 23 pregnancies resuited in single babies, 6 in twins, 1 in triplets and 10 in abortion. Twelve single pregnancies were clinically normal and were used as a control group to estimate the mean and 95% confidence limits of the 24-hour excretions, and the mean and 95% confidence limits of the weekly rates of increase of each hormone excreted. These figures were used to determine if threatened abortion, abortion, pre-eclamptic toxaemia or multiple pregnancy could be predicted from the excretion of the hormones. Abnormally low excretion of at least 1 of the steroids occurred before clinical evidence of threatened abortion in 4 of 10 cases, abortion in 6 of 10 cases and pre-eclamptic toxaemia in 3 of 8 cases. The excretion of all steroids appeared to be raised in multiple pregnancies but the difference between the mean of these and the mean for single pregnancies was not significant, probably because of the wide scatter. The usefulness of hormone assays in pregnancy is discussed.

          Related collections

          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1971
          1971
          21 November 2008
          : 2
          : 5
          : 302-320
          Affiliations
          The United Birmingham Hospitals, Department of Clinical Endocrinology, Birmingham and Midland Hospital for Women, Birmingham
          Article
          178243 Hormones 1971;2:302–320
          10.1159/000178243
          © 1971 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 19
          Categories
          Paper

          Comments

          Comment on this article