Cepharanthine and Piperine ameliorate diabetic nephropathy in rats: role of NF-κB and NLRP3 inflammasome.

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Abstract

Hyperglycemia leads to elevation of oxidative stress and proinflammatory cytokines which are the main causes of diabetic nephropathy (DN). NLRP3 inflammasome and thioredoxin-interacting protein (TXNIP) are recently assumed to participate in the development of DN. We aimed to investigate the effects of Cepharanthine (CEP), Piperine (Pip) and their combination in streptozotocin (STZ)-induced DN focusing on their role to modulate NLRP3 and TXNIP induced inflammation.

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Journal

Journal ID (iso-abbrev): Life Sci.

Title: Life sciences

Publisher: Elsevier BV

ISSN (Electronic): 1879-0631

ISSN (Print): 0024-3205

Publication date (Electronic): Jul 15 2016

Volume: 157

Affiliations

[1 ] Department of Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt. Electronic address: Yaraadel1290@yahoo.com.

[2 ] Department of Microbiology, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.

[3 ] Department of Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.

[4 ] Department of Ophthalmology, Augusta University, Augusta, GA 30912, USA.

[5 ] Department of Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt. Electronic address: lailaeissa2002@yahoo.com.

Article

Publisher Item ID: S0024-3205(16)30348-4

DOI: 10.1016/j.lfs.2016.06.002

PubMed ID: 27266851

SO-VID: 28a70bc1-132d-4204-866e-b311abbac6da

History

Keywords: Cepharanthine,Diabetes,NF-κB,NLRP3,Piperine,Renal injury,TXNIP

Data availability:

Keywords: Cepharanthine, Diabetes, NF-κB, NLRP3, Piperine, Renal injury, TXNIP

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