Caring for infants with negative reactive temperament may tax parents' confidence in their caregiving ability, or parenting self-efficacy (PSE). This may happen in particular in parents who interpret these signals as negative feedback on their performance. To test this hypothesis, 179 first-time pregnant women were presented a caregiving simulation that provided positive and negative feedback on their attempts to comfort a crying baby. According to their PSE resilience to negative feedback during the task, they were grouped in a high resilient and low resilient group. PSE was followed up at 32 weeks of pregnancy and 3 and 12 months after birth, while perceived temperament of the child was assessed at 3 and 12 months after birth. Results showed that among women with low resilience against negative feedback, perceived negative temperament was negatively associated with PSE at 3 months, whereas no such association was observed among women with high resilience against negative feedback. Implications of the concept of resilience for the study of PSE are discussed.