Full-field electroretinogram recorded with skin electrodes in 6- to 12-year-old children

Abstract

Purpose

To determine the full-field electroretinogram (ffERG) parameters, including the light-adapted (LA) 3 ERG and the photopic negative response (PhNR), in 6- to 12-year-old children.

Methods

ffERG data were obtained from 214 eyes of 214 healthy subjects. The amplitudes and peak time of the ffERG responses were obtained from children divided into 6- to 8-year-old and 9- to 12-year-old groups. Using a skin electrode, electrical signals were measured in response to white stimulating light and white background light (LA 3 ERG). A blue background light and red flashes were then used to elicit the PhNR.

Results

The a-wave amplitude ranged from 0.40 to 9.20 μV, the b-wave ranged from 4.70 to 30.80 μV, and the PhNR ranged from 1.30 to 39.90 μV. The b-wave peak time (33.20 ms) of 6- to 8-year-old groups was slightly shorter than that of the 9- to 12-year-old groups (33.60 ms, P =  0.01), but no differences in amplitudes or in peak time of other components. There were significant correlations between the amplitudes (a-wave and b-wave: r = 0.43, p < 0.001; a-wave and PhNR: r =  0.25, p <  0.001; b-wave and PhNR: r =  0.45, p <  0.001). There was a moderate correlation between the a-wave and b-wave peak time ( r =  0.31, P <  0.001).

Conclusions

We determined the largest dataset of the LA 3 ERG and PhNR parameters in a population of healthy children, aged 6–12 years, which may provide a useful reference value when evaluating children with potential retinal defects.