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Selective activation of angiotensin AT2 receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis.
E Bruce
1 ,
V Shenoy ,
A Rathinasabapathy ,
A Espejo ,
A Horowitz ,
A Oswalt ,
J Francis ,
A Nair ,
T Unger ,
M K Raizada ,
U M Steckelings ,
C Sumners ,
M J Katovich
May 2015
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Abstract
Pulmonary hypertension (PH) is a devastating disease characterized by increased pulmonary arterial pressure, which progressively leads to right-heart failure and death. A dys-regulated renin angiotensin system (RAS) has been implicated in the development and progression of PH. However, the role of the angiotensin AT2 receptor in PH has not been fully elucidated. We have taken advantage of a recently identified non-peptide AT2 receptor agonist, Compound 21 (C21), to investigate its effects on the well-established monocrotaline (MCT) rat model of PH.