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      Role of reactive oxygen species (ROS) in apoptosis induction.

      Apoptosis

      Animals, Apoptosis, physiology, Humans, Reactive Oxygen Species

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          Abstract

          Reactive oxygen species (ROS) and mitochondria play an important role in apoptosis induction under both physiologic and pathologic conditions. Interestingly, mitochondria are both source and target of ROS. Cytochrome c release from mitochondria, that triggers caspase activation, appears to be largely mediated by direct or indirect ROS action. On the other hand, ROS have also anti-apoptotic effects. This review focuses on the role of ROS in the regulation of apoptosis, especially in inflammatory cells.

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          11256882

          Chemistry

          Animals, Apoptosis, physiology, Humans, Reactive Oxygen Species

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