For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
2
views
49
references
 Top references
cited by
3
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      531
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Antioxidant and Hypolipidemic Activities of Acid-Depolymerised Exopolysaccharides by Termitomyces albuminosus

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The acid-depolymerised exopolysaccharides (ADES) of Termitomyces albuminosus were obtained, and the major fraction of ADES1 was isolated and purified by DEAE-52 cellulose anion-exchange column chromatography. Physicochemical characterizations showed that ADES1 was an α- and a β-configuration with the molecular weight of 2.43 kDa, containing (1→3, 4)-linked-Glc p, (1→4)-linked-D-Glc p, (1→3)-linked-D-Xyl p, (1→4)-linked-D-Man p, T-Glc p, (1→6)-linked-D-Gal p, and (1→4)-linked-L-Ara p. The in vivo assays showed that ADES1 could reduce lipid levels in the serum and liver, decrease serum enzyme activities, and improve antioxidant enzyme activities and p-AMPK α expressions in hyperlipidemic mice, which were also confirmed by histopathological observations. These data indicated that ADES1 might be considered as a novel substance to treat and prevent hyperlipidemia and as a hepatoprotective agent.

          Related collections

          Most cited references49

          • Record: found
          • Abstract: not found
          • Article: not found

          Hydroperoxide metabolism in mammalian organs.

          B. Chance, H Sies, A Boveris (1979)
          Article 0 comments Cited 559 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease.

            T Heitzer, T Schlinzig, K Krohn … (2001)
            Endothelial function is impaired in coronary artery disease and may contribute to its clinical manifestations. Increased oxidative stress has been linked to impaired endothelial function in atherosclerosis and may play a role in the pathogenesis of cardiovascular events. This study was designed to determine whether endothelial dysfunction and vascular oxidative stress have prognostic impact on cardiovascular event rates in patients with coronary artery disease. Endothelium-dependent and -independent vasodilation was determined in 281 patients with documented coronary artery disease by measuring forearm blood flow responses to acetylcholine and sodium nitroprusside using venous occlusion plethysmography. The effect of the coadministration of vitamin C (24 mg/min) was assessed in a subgroup of 179 patients. Cardiovascular events, including death from cardiovascular causes, myocardial infarction, ischemic stroke, coronary angioplasty, and coronary or peripheral bypass operation, were studied during a mean follow-up period of 4.5 years. Patients experiencing cardiovascular events (n=91) had lower vasodilator responses to acetylcholine (P<0.001) and sodium nitroprusside (P<0.05), but greater benefit from vitamin C (P<0.01). The Cox proportional regression analysis for conventional risk factors demonstrated that blunted acetylcholine-induced vasodilation (P=0.001), the effect of vitamin C (P=0.001), and age (P=0.016) remained independent predictors of cardiovascular events. Endothelial dysfunction and increased vascular oxidative stress predict the risk of cardiovascular events in patients with coronary artery disease. These data support the concept that oxidative stress may contribute not only to endothelial dysfunction but also to coronary artery disease activity.
            Article 0 comments Cited 372 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders.

              Benoit Viollet, S Horman, Renaud Dentin … (2006)
              It is now becoming evident that the liver has an important role in the control of whole body metabolism of energy nutrients. In this review, we focus on recent findings showing that AMP-activated protein kinase (AMPK) plays a major role in the control of hepatic metabolism. AMPK integrates nutritional and hormonal signals to promote energy balance by switching on catabolic pathways and switching off ATP-consuming pathways, both by short-term effects on phosphorylation of regulatory proteins and by long-term effects on gene expression. Activation of AMPK in the liver leads to the stimulation of fatty acid oxidation and inhibition of lipogenesis, glucose production and protein synthesis. Medical interest in the AMPK system has recently increased with the demonstration that AMPK could mediate some of the effects of the fat cell-derived adiponectin and the antidiabetic drugs metformin and thiazolidinediones. These findings reinforce the idea that pharmacological activation of AMPK may provide, through signalling and metabolic and gene expression effects, a new strategy for the management of metabolic hepatic disorders linked to type 2 diabetes and obesity.
              Article 0 comments Cited 161 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Luzhang Wan:
                ORCID: https://orcid.org/0000-0002-5213-820X
                Le Jia:
                ORCID: https://orcid.org/0000-0002-1084-3517
                Journal
                Journal ID (nlm-ta): Oxid Med Cell Longev
                Journal ID (iso-abbrev): Oxid Med Cell Longev
                Journal ID (publisher-id): OMCL
                Title: Oxidative Medicine and Cellular Longevity
                Publisher: Hindawi
                ISSN (Print): 1942-0900
                ISSN (Electronic): 1942-0994
                Publication date Collection: 2019
                Publication date (Electronic): 8 September 2019
                Volume: 2019
                Electronic Location Identifier: 8915272
                Affiliations
                1Institute of Agricultural Resources and Environment, Shandong Academy of Agricultural Science, Jinan 250100, China
                2College of Life Science, Shandong Agricultural University, Taian 271018, China
                Author notes

                Academic Editor: Janusz Gebicki

                Author information
                https://orcid.org/0000-0001-6168-5988
                https://orcid.org/0000-0002-5213-820X
                https://orcid.org/0000-0002-1084-3517
                Article
                DOI: 10.1155/2019/8915272
                PMC ID: 6754963
                SO-VID: 2a89c8c9-cb56-475f-bebc-437000476e52
                Copyright © Copyright © 2019 Huajie Zhao et al.
                License:

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 11 January 2019
                Date revision received : 21 May 2019
                Date accepted : 29 May 2019
                Funding
                Funded by: Shandong Province
                Award ID: SDAIT-07-05
                Categories
                Subject: Research Article

                ScienceOpen disciplines: Molecular medicine
                Data availability:
                ScienceOpen disciplines: Molecular medicine

                Comments

                Comment on this article

                scite_

                Similar content531

                See all similar

                Cited by3

                See all cited by

                Most referenced authors989

                See all reference authors