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      Knowledge and attitude towards monkeypox among the Lebanese population and their attitude towards vaccination

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          Summary

          Introduction

          Monkeypox is a currently re-emerging disease in the world and several cases have been detected in Lebanon. For this reason, an assessment of the knowledge and attitude of the Lebanese population towards monkeypox and smallpox or monkeypox vaccines had to be done.

          Methods

          A cross-sectional study was conducted using a questionnaire developed from previous literature among a sample of Lebanese residents. It recorded the sociodemographic characteristics and comorbidities of the participants and analyzed the patterns of knowledge and attitudes in Lebanon.

          Results

          Among 493 participants, it was found that there is a generally low knowledge of and an average attitude toward monkeypox. However, knowledge is better with higher educational levels, COVID-19 vaccination, and residency in the south of Lebanon and poorer with marriage and residency in Beirut. Attitude is better in females but poorer with higher educational levels. Several other effectors have been devised too. As for vaccination, taking the smallpox vaccine as a proactive measure is predicted with previous COVID-19 vaccination and better attitude but not in the residents of the north of Lebanon and married Lebanese residents. Higher educational levels and a better attitude were positive predictions of taking the monkeypox vaccine whenever it is developed.

          Conclusion

          This study revealed low level of knowledge and attitude towards monkeypox and its vaccines, which can be a rich resource when proactive measures are developed.

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          Most cited references23

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          The detection of monkeypox in humans in the Western Hemisphere.

          During May and June 2003, an outbreak of febrile illness with vesiculopustular eruptions occurred among persons in the midwestern United States who had had contact with ill pet prairie dogs obtained through a common distributor. Zoonotic transmission of a bacterial or viral pathogen was suspected. We reviewed medical records, conducted interviews and examinations, and collected blood and tissue samples for analysis from 11 patients and one prairie dog. Histopathological and electron-microscopical examinations, microbiologic cultures, and molecular assays were performed to identify the etiologic agent. The initial Wisconsin cases evaluated in this outbreak occurred in five males and six females ranging in age from 3 to 43 years. All patients reported having direct contact with ill prairie dogs before experiencing a febrile illness with skin eruptions. We found immunohistochemical or ultrastructural evidence of poxvirus infection in skin-lesion tissue from four patients. Monkeypox virus was recovered in cell cultures of seven samples from patients and from the prairie dog. The virus was identified by detection of monkeypox-specific DNA sequences in tissues or isolates from six patients and the prairie dog. Epidemiologic investigation suggested that the prairie dogs had been exposed to at least one species of rodent recently imported into the United States from West Africa. Our investigation documents the isolation and identification of monkeypox virus from humans in the Western Hemisphere. Infection of humans was associated with direct contact with ill prairie dogs that were being kept or sold as pets. Copyright 2004 Massachusetts Medical Society
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            A tale of two clades: monkeypox viruses.

            Human monkeypox was first recognized outside Africa in 2003 during an outbreak in the USA that was traced to imported monkeypox virus (MPXV)-infected West African rodents. Unlike the smallpox-like disease described in the Democratic Republic of the Congo (DRC; a Congo Basin country), disease in the USA appeared milder. Here, analyses compared clinical, laboratory and epidemiological features of confirmed human monkeypox case-patients, using data from outbreaks in the USA and the Congo Basin, and the results suggested that human disease pathogenicity was associated with the viral strain. Genomic sequencing of USA, Western and Central African MPXV isolates confirmed the existence of two MPXV clades. A comparison of open reading frames between MPXV clades permitted prediction of viral proteins that could cause the observed differences in human pathogenicity between these two clades. Understanding the molecular pathogenesis and clinical and epidemiological properties of MPXV can improve monkeypox prevention and control.
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              A POX-LIKE DISEASE IN CYNOMOLGUS MONKEYS

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                Author and article information

                Journal
                J Prev Med Hyg
                J Prev Med Hyg
                JPMH
                Journal of Preventive Medicine and Hygiene
                Pacini Editore Srl
                1121-2233
                2421-4248
                16 May 2023
                March 2023
                : 64
                : 1
                : E13-E26
                Affiliations
                [1 ] Medical Research Center, Faculty of medical sciences, Lebanese University , Hadath, Lebanon
                [2 ] Gilbert and Rose Marie Chagoury School of Medicine, Lebanese American University , Byblos, Lebanon
                [3 ] Neuroscience Research Center, Faculty of Medical Sciences, Lebanese University , Hadath, Lebanon
                [4 ] Faculty of Medical Sciences, Université Saint Joseph , Beirut, Lebanon
                [5 ] Faculty of Medical Sciences, Lebanese University , Hadath, Lebanon
                [6 ] Faculty of Medicine, Beirut Arab University , Beirut, Lebanon
                [7 ] Institut National de Santé Publique, Epidémiologie Clinique et Toxicologie (INSPECT-LB) , Lebanon
                [8 ] University of Nicosia Medical School , Nicosia, Cyprus
                Author notes
                Correspondence: Youssef Jamaleddine, Medical Research Center, Faculty of medical sciences, Lebanese University, Hadath, Lebanon. Tel. +961 81650657 - E-mail: youssefjd@ 123456outlook.com
                Article
                10.15167/2421-4248/jpmh2023.64.1.2903
                10246610
                37293454
                2b00c5bc-a20b-420f-b2b0-2398acb1a79d
                ©2023 Pacini Editore SRL, Pisa, Italy

                This is an open access article distributed in accordance with the CC-BY-NC-ND (Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International) license. The article can be used by giving appropriate credit and mentioning the license, but only for non-commercial purposes and only in the original version. For further information: https://creativecommons.org/licenses/by-nc-nd/4.0/deed.en

                History
                : 29 March 2023
                : 18 April 2023
                Page count
                Figures: 0, Tables: 12, Equations: 0, References: 31, Pages: 14
                Categories
                Infectious Diseases

                monkeypox,attitude,knowledge,practice,virus,lebanon
                monkeypox, attitude, knowledge, practice, virus, lebanon

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