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      Safety and efficacy of clonazepam in patients with hemifacial spasm: A double-blind, randomized, placebo-controlled trial.

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          Abstract

          Hemifacial spasm (HFS) is an involuntary intermittent twitching of the facial muscles. Medical and surgical treatments can be considered for HFS. Among medical treatments, clonazepam is a benzodiazepine used to treat epilepsy, psychiatric symptoms, and movement disorders. This study aimed to investigate the efficacy and safety of clonazepam for the treatment of HFS.

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          Author and article information

          Journal
          Journal ID (iso-abbrev): Parkinsonism Relat Disord
          Title: Parkinsonism & related disorders
          Publisher: Elsevier BV
          ISSN (Electronic): 1873-5126
          ISSN (Print): 1353-8020
          Publication date (Electronic): Oct 2022
          Volume: 103
          Affiliations
          [1 ] Department of Neurology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
          [2 ] Department of Neurology, Neuroscience Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
          [3 ] Department of Neurology, Ajou University Medical Center, Ajou University College of Medicine, Suwon, Republic of Korea.
          [4 ] Department of Neurology, Seoul Medical Center, Seoul, Republic of Korea.
          [5 ] Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea.
          [6 ] Department of Neurology, SM christianity hospital, Pohang, Republic of korea.
          [7 ] Department of Neurology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea.
          [8 ] Department of Neurology, Konkuk University Medical Center, Seoul, Republic of Korea.
          [9 ] Department of Neurology, Neuroscience Research Institute, Medical Research Council, Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul, Republic of Korea.
          [10 ] Department of Neurology, Neuroscience Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address: jjsaint@snu.ac.kr.
          Article
          Publisher Item ID: S1353-8020(22)00250-4
          DOI: 10.1016/j.parkreldis.2022.07.025
          PubMed ID: 35987013
          SO-VID: 2ba91843-0e78-4938-a6f8-e6e505fcb60f
          History

          Keywords: Hemifacial spasm,Efficacy,Safety,Clonazepam
          Data availability:
          Keywords: Hemifacial spasm, Efficacy, Safety, Clonazepam

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