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      The Impact of Stressful Life Events on Excessive Alcohol Consumption in the French Population: Findings from the GAZEL Cohort Study

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          Abstract

          Background

          Major life changes may play a causative role in health through lifestyle factors, such as alcohol. The objective was to examine the impact of stressful life events on heavy alcohol consumption among French adults.

          Methods

          Trajectories of excessive alcohol consumption in 20,625 employees of the French national gas and electricity company for up to 5 years before and 5 years after an event, with annual measurements from 1992. We used repeated measures analysis of time series data indexed to events, employing generalized estimating equations.

          Results

          For women, excessive alcohol use increased before important purchase (p = 0.021), children leaving home (p<0.001), and death of loved ones (p = 0.03), and decreased before widowhood (p = 0.015); in the year straddling the event, increased consumption was observed for important purchase (p = 0.018) and retirement (p = 0.002); at the time of the event, consumption decreased for marriage (p = 0.002), divorce, widowhood, and death of loved one (all p<0.001), and increased for retirement (p = 0.035). For men, heavy alcohol consumption increased in the years up to and surrounding the death of loved ones, retirement, and important purchase (all p<0.001), and decreased after (all p<0.001, except death of loved one: p = 0.006); at the time of the event, consumption decreased for all events except for children leaving home and retirement, where we observed an increase (all p<0.001). For women and men, heavy alcohol consumption decreased prior to marriage and divorce and increased after (all p<0.001, except for women and marriage: p = 0.01).

          Conclusion

          Stressful life events promote healthy and unhealthy alcohol consumption. Certain events impact alcohol intake temporarily while others have longer-term implications. Research should disentangle women's and men's distinct perceptions of events over time.

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          Most cited references30

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          Positive affect and the complex dynamics of human flourishing.

          Extending B. L. Fredrickson's (1998) broaden-and-build theory of positive emotions and M. Losada's (1999) nonlinear dynamics model of team performance, the authors predict that a ratio of positive to negative affect at or above 2.9 will characterize individuals in flourishing mental health. Participants (N=188) completed an initial survey to identify flourishing mental health and then provided daily reports of experienced positive and negative emotions over 28 days. Results showed that the mean ratio of positive to negative affect was above 2.9 for individuals classified as flourishing and below that threshold for those not flourishing. Together with other evidence, these findings suggest that a set of general mathematical principles may describe the relations between positive affect and human flourishing. ((c) 2005 APA, all rights reserved).
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            The Social Readjustment Rating Scale.

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              Transduction of psychosocial stress into the neurobiology of recurrent affective disorder.

              Early clinical observations and recent systematic studies overwhelmingly document a greater role for psychosocial stressors in association with the first episode of major affective disorder than with subsequent episodes. The author postulates that both sensitization to stressors and episode sensitization occur and become encoded at the level of gene expression. In particular, stressors and the biochemical concomitants of the episodes themselves can induce the protooncogene c-fos and related transcription factors, which then affect the expression of transmitters, receptors, and neuropeptides that alter responsivity in a long-lasting fashion. Thus, both stressors and episodes may leave residual traces and vulnerabilities to further occurrences of affective illness. These data and concepts suggest that the biochemical and anatomical substrates underlying the affective disorders evolve over time as a function of recurrences, as does pharmacological responsivity. This formulation highlights the critical importance of early intervention in the illness in order to prevent malignant transformation to rapid cycling, spontaneous episodes, and refractoriness to drug treatment.
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                Author and article information

                Contributors
                Role: Editor
                Journal
                PLoS One
                PLoS ONE
                plos
                plosone
                PLoS ONE
                Public Library of Science (San Francisco, USA )
                1932-6203
                2014
                27 January 2014
                : 9
                : 1
                : e87653
                Affiliations
                [1 ]Department of Social and Behavioral Sciences, Harvard School of Public Health, Boston, Massachusetts, United States of America
                [2 ]Center for Community-Based Research, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
                [3 ]Mathematica Policy Research, Cambridge, Massachusetts, United States of America
                [4 ]INSERM, UMRS 1018, Centre for Research in Epidemiology and Population Health, Population-based Cohorts Research Platform, Villejuif, France
                [5 ]Université de Versailles Saint-Quentin, Versailles, France
                University of Granada, Spain
                Author notes

                Competing Interests: The authors have the following interests: this study was partly funded by EDF-GDF. Co-author Alex A. Bohl is employed by Mathematica Policy Research. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

                Conceived and designed the experiments: ST. Analyzed the data: AB. Wrote the paper: ST CO AB AG MG MZ.

                Article
                PONE-D-13-08134
                10.1371/journal.pone.0087653
                3903768
                24475318
                2bacb063-cfcb-43af-a423-be345a49dadc
                Copyright @ 2014

                This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 22 February 2013
                : 2 January 2014
                Page count
                Pages: 8
                Funding
                This research was supported by the EDF-GDF, l'INSERM, l'Association de la Recherche sur le Cancer, la Fondation de France, le Ministère de la Santé, the NIH/NCI Harvard Education Program in Cancer Prevention (R25 CA057713; PI: Glorian Sorensen, PhD), and the NIH/NCI Reducing Social Disparities in Cancer Risk (K05 CA108663-05 to GS). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
                Categories
                Research Article
                Medicine
                Clinical Research Design
                Longitudinal Studies
                Epidemiology
                Lifecourse Epidemiology
                Geriatrics
                Global Health
                Mental Health
                Psychology
                Psychological Stress
                Non-Clinical Medicine
                Public Health
                Alcohol
                Social and Behavioral Sciences
                Psychology
                Psychological Stress

                Uncategorized
                Uncategorized

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