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      Speculations on the Mechanism of Action of Insulin

      Hormone Research in Paediatrics

      S. Karger AG

      Insulin, Mitochondria, pH, Citrate, Conformation, Respiration, RNA, Nucleus

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          Abstract

          Insulin affects many processes in muscle and it is difficultto envisage ways in which all these effects can result from a single primary action. Nonetheless it is of interest to speculate how the different actions of the hormone could be linked to each other. The possibility that insulin might induce a conformational change in responsive tissues is considered and how such need not include nuclear events. An alter native suggestion would be for insulin to induce a small rise in intra cellular pH. Such would favour many pH-sensitive reactions and is indicated by studies of the distribution in muscle of DMO and CO<sub>2</sub>/bicarbonate. These results direct attention towards functions of the mitochondria, and a possible explanation of why respiration is not affected by insulin despite changing anabolic load is considered. Mitochondria are very active in translocating ions. Possible ways in which movements of ions in response to pH could affect metabolism are put forward.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1970
          1970
          21 November 2008
          : 1
          : 6
          : 342-351
          Affiliations
          Department of Biochemistry, University College London
          Article
          178194 Hormones 1970;1:342–351
          10.1159/000178194
          © 1970 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 10
          Categories
          Paper

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