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Gastrointestinal safety of celecoxib versus naproxen in patients with cardiothrombotic diseases and arthritis after upper gastrointestinal bleeding (CONCERN): an industry-independent, double-blind, double-dummy, randomised trial
Francis K L Chan ,
Jessica Y L Ching ,
Yee Kit Tse ,
Kelvin Lam ,
Grace L H Wong ,
Siew C Ng ,
Vivian Lee ,
Kim W L Au ,
Pui Kuan Cheong ,
Bing Y Suen ,
Heyson Chan ,
Ka Man Kee ,
Angeline Lo ,
Vincent W S Wong ,
Justin C Y Wu ,
Moe H Kyaw
June 2017
June 2017
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Abstract
Present guidelines are conflicting for patients at high risk of both cardiovascular
and gastrointestinal events who continue to require non-steroidal anti-inflammatory
drugs (NSAIDs). We hypothesised that a cyclooxygenase-2-selective NSAID plus proton-pump
inhibitor is superior to a non-selective NSAID plus proton-pump inhibitor for prevention
of recurrent ulcer bleeding in concomitant users of aspirin with previous ulcer bleeding.