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      Gastrointestinal safety of celecoxib versus naproxen in patients with cardiothrombotic diseases and arthritis after upper gastrointestinal bleeding (CONCERN): an industry-independent, double-blind, double-dummy, randomised trial

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          Abstract

          Present guidelines are conflicting for patients at high risk of both cardiovascular and gastrointestinal events who continue to require non-steroidal anti-inflammatory drugs (NSAIDs). We hypothesised that a cyclooxygenase-2-selective NSAID plus proton-pump inhibitor is superior to a non-selective NSAID plus proton-pump inhibitor for prevention of recurrent ulcer bleeding in concomitant users of aspirin with previous ulcer bleeding.

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          Author and article information

          Journal
          The Lancet
          The Lancet
          Elsevier BV
          01406736
          June 2017
          June 2017
          : 389
          : 10087
          : 2375-2382
          Article
          10.1016/S0140-6736(17)30981-9
          28410791
          © 2017

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