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      Identifying Adverse Childhood Experiences in Pediatrics to Prevent Chronic Health Conditions

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          Abstract

          Despite evidence that over 40% of youth in the US have one or more adverse childhood experiences (ACEs), and that ACEs have cumulative, pernicious effects on lifelong health, few primary care clinicians routinely ask about ACEs. Lack of standardized and accurate clinical assessments for ACEs, combined with no point-of-care biomarkers of the “toxic stress” caused by ACEs, hampers prevention of the health consequences of ACEs. Thus, there is no consensus regarding how to identify, screen and track ACEs, and whether early identification of toxic stress can prevent disease. In this review, we aim to clarify why, for whom, when, and how to identify ACEs in pediatric clinical care. To do so, we examine the evidence for such identification; describe the efficacy and accuracy of potential screening instruments; discuss current trends in, and potential barriers to, the identification of ACEs and the prevention of downstream effects; and recommend next steps for research, practice, and policy.

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          Most cited references72

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          Ordinary magic. Resilience processes in development.

          The study of resilience in development has overturned many negative assumptions and deficit-focused models about children growing up under the threat of disadvantage and adversity. The most surprising conclusion emerging from studies of these children is the ordinariness of resilience. An examination of converging findings from variable-focused and person-focused investigations of these phenomena suggests that resilience is common and that it usually arises from the normative functions of human adaptational systems, with the greatest threats to human development being those that compromise these protective systems. The conclusion that resilience is made of ordinary rather than extraordinary processes offers a more positive outlook on human development and adaptation, as well as direction for policy and practice aimed at enhancing the development of children at risk for problems and psychopathology.
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            Development and validation of a brief screening version of the Childhood Trauma Questionnaire.

            The goal of this study was to develop and validate a short form of the Childhood Trauma Questionnaire (the CTQ-SF) as a screening measure for maltreatment histories in both clinical and nonreferred groups. Exploratory and confirmatory factor analyses of the 70 original CTQ items were used to create a 28-item version of the scale (25 clinical items and three validity items) and test the measurement invariance of the 25 clinical items across four samples: 378 adult substance abusing patients from New York City, 396 adolescent psychiatric inpatients, 625 substance abusing individuals from southwest Texas, and 579 individuals from a normative community sample (combined N=1978). Results showed that the CTQ-SF's items held essentially the same meaning across all four samples (i.e., measurement invariance). Moreover, the scale demonstrated good criterion-related validity in a subsample of adolescents on whom corroborative data were available. These findings support the viability of the CTQ-SF across diverse clinical and nonreferred populations.
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              Psychological stress and cardiovascular disease.

              There is an enormous amount of literature on psychological stress and cardiovascular disease. This report reviews conceptual issues in defining stress and then explores the ramifications of stress in terms of the effects of acute versus long-term stressors on cardiac functioning. Examples of acute stressor studies are discussed in terms of disasters (earthquakes) and in the context of experimental stress physiology studies, which offer a more detailed perspective on underlying physiology. Studies of chronic stressors are discussed in terms of job stress, marital unhappiness, and burden of caregiving. From all of these studies there are extensive data concerning stressors' contributions to diverse pathophysiological changes including sudden death, myocardial infarction, myocardial ischemia, and wall motion abnormalities, as well as to alterations in cardiac regulation as indexed by changes in sympathetic nervous system activity and hemostasis. Although stressors trigger events, it is less clear that stress "causes" the events. There is nonetheless overwhelming evidence both for the deleterious effects of stress on the heart and for the fact that vulnerability and resilience factors play a role in amplifying or dampening those effects. Numerous approaches are available for stress management that can decrease patients' suffering and enhance their quality of life.
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                Author and article information

                Journal
                0100714
                6400
                Pediatr Res
                Pediatr. Res.
                Pediatric research
                0031-3998
                1530-0447
                19 October 2019
                17 October 2019
                January 2020
                17 April 2020
                : 87
                : 2
                : 362-370
                Affiliations
                [1 ]Department of Pediatrics, University of Minnesota
                [2 ]Department of Psychiatry, University of Colorado
                [3 ]Institute of Child Development, University of Minnesota
                [4 ]Department of Psychiatry and Behavioral Sciences, University of Minnesota
                [5 ]Departments of Pediatrics, Health Outcomes and Policy, University of Florida
                Author notes

                Authorship Statement: All authors had substantial contributions to the concept, design, and critical review of the literature for this narrative review article; drafting the article and revising it critically for important intellectual content; and have given their final approval of the version to be published. All authors have agreed to its submission; it is not currently being considered for publication by another journal, and it will not published in the same or similar form in any language without the consent of publishers.

                Address correspondence to: Andrew J. Barnes Department of Pediatrics, University of Minnesota, 717 Delaware Street SE, Room 353 Minneapolis, MN 55414; drbarnes@ 123456umn.edu ; (612) 624-1167
                Article
                NIHMS1541079
                10.1038/s41390-019-0613-3
                6962546
                31622974
                2cc7fc7f-a7fb-41f3-97c9-bf3fd135148d

                Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms

                History
                Categories
                Article

                Pediatrics
                screening,social determinants of health,psychosocial factors
                Pediatrics
                screening, social determinants of health, psychosocial factors

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