Effect of main ingredients of Danhong Injection against oxidative stress induced autophagy injury via miR-19a/SIRT1 pathway in endothelial cells.

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Abstract

Autophagy plays an important role in cellular homeostasis. Oxidative stress stimulated endothelial excessive autophagy has been proposed as a major risk factor for cardiovascular diseases (CVD). Danhong injection (DHI), the most prescribed traditional Chinese medicine for the treatment of CVD, has been shown to elicit vascular protective effects. However, its underlying mechanisms remain poorly defined. This study aimed to uncover the protective effects of DHI and its main bioactive components on autophagy injury of human umbilical vein endothelial cells (HUVECs) induced by H2O2 and reveal the possible mechanisms.

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Journal

Journal ID (iso-abbrev): Phytomedicine

Title: Phytomedicine : international journal of phytotherapy and phytopharmacology

Publisher: Elsevier BV

ISSN (Electronic): 1618-095X

ISSN (Print): 0944-7113

Publication date (Electronic): Mar 2021

Volume: 83

Affiliations

[1 ] College of Basic Medicine &Public Health, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China; College of Life Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China. Electronic address: joygy1401@163.com.

[2 ] College of Basic Medicine &Public Health, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China. Electronic address: yjhong@zcmu.edu.cn.

[3 ] College of Life Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China. Electronic address: 1714057953@qq.com.

[4 ] College of Life Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China. Electronic address: zjtcmgcx@126.com.

[5 ] College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China. Electronic address: heyu0923@sina.com.

[6 ] College of Life Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China. Electronic address: wangyu@zcmu.edu.cn.

[7 ] College of Life Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China. Electronic address: whtong@126.com.

[8 ] College of Life Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China. Electronic address: jinbo@zcmu.edu.cn.

Article

Publisher Item ID: S0944-7113(21)00022-2

DOI: 10.1016/j.phymed.2021.153480

PubMed ID: 33548866

SO-VID: 2cd91fcc-6869-4433-9bdc-686d5994e973

History

Keywords: human umbilical vein endothelial cells,miR-19a,oxidative autophagy,SIRT1,Danhong injection and its components

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Keywords: human umbilical vein endothelial cells, miR-19a, oxidative autophagy, SIRT1, Danhong injection and its components

Effect of main ingredients of Danhong Injection against oxidative stress induced autophagy injury via miR-19a/SIRT1 pathway in endothelial cells.

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