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      Metastatic Directed Therapy in Oligometastatic Prostate Cancer

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      Journal of Men's Health
      Dougmar Publishing Group, Inc.

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          Review of major adverse effects of androgen-deprivation therapy in men with prostate cancer.

          Androgen-deprivation therapy (ADT) is a common treatment for men with prostate cancer. Although ADT is effective at suppressing prostate-specific antigen (PSA), stabilizing disease, alleviating symptoms in advanced disease, and potentially prolonging survival, it is not without serious side effects. However, to the authors' knowledge, there is lack of a systematic review of its major adverse effects to date. The authors of this report systematically reviewed and quantitatively assessed the literature on skeletal and cardiac side effects associated with ADT in men with prostate cancer. The PubMed database was searched for relevant published articles from 1966 to May 2008, and 683 articles were reviewed systematically from an original 20 different Medical Subject Heading search combinations. The focus of the review was on bone-related and cardiovascular-related outcomes. When appropriate, results were pooled from articles on specific adverse outcomes, summary risk estimates were calculated, and tests of heterogeneity were performed. Fourteen articles were identified that met inclusion criteria from the original 683 studies. Men who underwent ADT for prostate cancer had a significantly increased risk of overall fracture of 23% (summary relative risk, 1.23; 95% confidence interval [95% CI], 1.10-1.38) compared with men who had prostate cancer but who did not undergo ADT. Furthermore, men who underwent ADT had a 17% increase in cardiovascular-related mortality compared with men who did not undergo with ADT (summary hazards ratio, 1.17; 95% CI, 1.07-1.29). Significant elevations in the risk of diabetes also were observed from 2 large studies. ADT was associated with an increased risk of skeletal fracture, incident diabetes, and cardiovascular-related mortality, although the absolute risk of these events was low. Preventive measures against these adverse effects and careful assessment of patient's baseline health status should be considered. (c) 2009 American Cancer Society.
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            STOMPing Out Hormone-Sensitive Metastases With Local Therapies in Prostate Cancer

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              Author and article information

              Journal
              Journal of Men's Health
              J Men's Health
              Dougmar Publishing Group, Inc.
              1875-6859
              June 07 2018
              June 07 2018
              : 14
              : 3
              : e1-e2
              Article
              10.22374/1875-6859.14.3.3
              2d7f1130-8968-4568-b3c4-8f7ec6c79d32
              © 2018

              Copyright of articles published in all DPG titles is retained by the author. The author grants DPG the rights to publish the article and identify itself as the original publisher. The author grants DPG exclusive commercial rights to the article. The author grants any non-commercial third party the rights to use the article freely provided original author(s) and citation details are cited. To view a copy of this license, visit https://creativecommons.org/licenses/by-nc/4.0/

              History

              Geriatric medicine,Urology,Sports medicine,Sexual medicine
              Geriatric medicine, Urology, Sports medicine, Sexual medicine

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