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      Cemented versus uncemented femoral component total hip arthroplasty in elderly patients with primary osteoporosis: retrospective analysis with 5-year follow-up

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          Abstract

          Objective

          To compare medium-term clinical and radiological outcomes of primary unilateral uncemented (UN) or cemented (CE) femoral component total hip arthroplasty (THA) in elderly patients with osteoporosis.

          Methods

          Consecutive patients with osteoporosis who underwent primary unilateral UN or CE THAs at our institution from 2006 to 2013 were retrospectively reviewed. All consecutive procedures were managed by high-volume surgeons, using UN or CE THA approaches. Follow-up assessments occurred at 1, 3, 6, 9, and 12 months postoperatively, and yearly thereafter. Patient-related functional outcomes were assessed using the Harris Hip Score (HHS). Primary and secondary endpoints were early revision (<5 years) and functional outcome.

          Results

          In total, 496 primary unilateral THAs (CE, n = 184; UN, n = 182) were assessed with a median follow-up period of 75 months (range, 65–86 months). From 3 months after surgery to the final follow-up, HHS was consistently superior in the CE group. Respective prosthetic loosening rates in the UN and CE groups were 26.4% and 16.8% at a minimum of 5 years. There was a significant difference in rate of early revision (7.6% CE vs. 14.8% UN).

          Conclusion

          Compared with UN THA, CE THA exhibits a superior outcome in elderly patients with primary osteoporosis.

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          Most cited references24

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          Ectopic ossification following total hip replacement. Incidence and a method of classification.

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            Diagnostic criteria for primary osteoporosis: year 2012 revision.

            In 1995, the Japanese Society for Bone and Mineral Metabolism (now the Japanese Society for Bone and Mineral Research) established the Osteoporosis Diagnostic Criteria Review Committee. Following discussion held at the 13th scientific meeting of the Society in 1996, the Committee, with the consensus of its members, proposed diagnostic criteria for primary osteoporosis. The Committee revised those criteria in 1998 and again in 2000. The Japanese Society for Bone and Mineral Research and Japan Osteoporosis Society Joint Review Committee for the Revision of the Diagnostic Criteria for Primary Osteoporosis aimed at obtaining international consistency and made a revised edition based on the new findings in 2012.
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              A Systematic Review and Meta-Analysis of Antibiotic-Impregnated Bone Cement Use in Primary Total Hip or Knee Arthroplasty

              Background Antibiotic-impregnated bone cement (AIBC) has been widely used for the treatment of infected revision arthroplasty, but its routine use in primary total joint arthroplasty (TJA) remains considerably controversial. With this meta-analysis of published randomized controlled trials, we intended to assess the antimicrobial efficacy and safety of AIBC for its prophylactic use in primary TJA. Methods A literature search was performed in MEDLINE, Embase, CBMdisc and the Cochrane Library until June, 2013. The studies were divided into two sub-groups according to the type of the control group. Outcomes of interest included postoperative infection rates, radiographic outcomes and clinical joint score. Study quality was evaluated using the Jadad scale (five points). Results In total, eight studies were included, with a sample size of 6,381 arthroplasties. The overall pooled data demonstrated that, compared with the control (plain cement or systemic antibiotic), AIBC did not reveal an advantage in decreasing the rate of superficial infection (relative risk [RR] = 1.47; 95% CI, 1.13–1.91; P=0.004), while there were significant differences in deep infection rate between the AIBC and control group (RR = 0.41; 95% CI, 0.17–0.97; P=0.04). For the analysis of gentamicin and cefuroxime subgroups, the gentamicin was superior to the cefuroxime in reducing deep infection rate (P=0.0005 versus P= 0.10). However, no significant differences were found in their radiographic outcomes and clinical joint score. Conclusion This meta-analysis had proven that the prophylactic use of AIBC could lower the deep infection rate in primary TJA, while AIBC did not show an improvement in reducing the superficial infection rate compared with the control. More sufficiently powered studies would be required to further evaluate the efficacy and safety of AIBC for primary TJA.
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                Author and article information

                Journal
                J Int Med Res
                J. Int. Med. Res
                IMR
                spimr
                The Journal of International Medical Research
                SAGE Publications (Sage UK: London, England )
                0300-0605
                1473-2300
                14 February 2019
                April 2019
                : 47
                : 4
                : 1610-1619
                Affiliations
                [1 ]Department of Physical Examination, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
                [2 ]Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
                [3 ]Department of Cardiac Function, Department of Cardiovascular Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Jianghan District, Wuhan, China
                [4 ]Department of Orthopaedics, Beijing Ditan Hospital, Capital Medical University, Jingshun East Street No. 8, Chaoyang District, Beijing, 100015, China
                [5 ]Guangzhou Sport University, Guangzhou, China
                [6 ]Department of Orthopaedics, Jinshan Hospital, Fudan University, Shanghai, China
                [7 ]Department of Orthopaedics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
                Author notes

                *These authors contributed equally to this work.

                [*]Tao Wang, Guangzhou Sport University, Guangzhou Avenue No.1268, Tianhe District, Guangzhou, 510500, China; Guowei Han, Department of Orthopedics, The First Affiliated Hospital of Sun Yat-sen University, Huangpu East Road No. 183, Huangpu District, Guangzhou, 510700, China. Email: tyronetao215@ 123456163 ; Hanson9797@ 123456163.com
                Author information
                https://orcid.org/0000-0002-6960-9856
                Article
                10.1177_0300060518825428
                10.1177/0300060518825428
                6460604
                30764684
                2dcd477b-8f75-4cf6-b030-a503bc60fbff
                © The Author(s) 2019

                Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License ( http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages ( https://us.sagepub.com/en-us/nam/open-access-at-sage).

                History
                : 2 September 2018
                : 28 December 2018
                Funding
                Funded by: Shanghai Municipal Health and Family Planning Commission Fund Project , FundRef ;
                Award ID: Grant No. 201640057
                Funded by: National Natural Science Foundation of China , FundRef ;
                Award ID: Grant No. 81770876; 81270011; 81472125
                Categories
                Clinical Research Reports

                total hip arthroplasty,revision,osteoporosis,failure,uncemented,cemented

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