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      MRI and muscle imaging for idiopathic inflammatory myopathies

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          Abstract

          Although idiopathic inflammatory myopathies (IIM) are a heterogeneous group of diseases nearly all patients display muscle inflammation. Originally, muscle biopsy was considered as the gold standard for IIM diagnosis. The development of muscle imaging led to revisiting not only the IIM diagnosis strategy but also the patients’ follow‐up. Different techniques have been tested or are in development for IIM including positron emission tomography, ultrasound imaging, ultrasound shear wave elastography, though magnetic resonance imaging (MRI) remains the most widely used technique in routine. Whereas guidelines on muscle imaging in myositis are lacking here we reviewed the relevance of muscle imaging for both diagnosis and myositis patients’ follow‐up. We propose recommendations about when and how to perform MRI on myositis patients, and we describe new techniques that are under development.

          Abstract

          Muscle imaging and especially muscle MRI is a powerful technique for both IIM diagnosis and follow‐up. Muscle MRI is actually the best muscle imaging technique in routine, and it is widely used, but guidelines determining when and how to use it in myositis patients are lacking.

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          Most cited references171

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          Skeletal muscle: a brief review of structure and function.

          Skeletal muscle is one of the most dynamic and plastic tissues of the human body. In humans, skeletal muscle comprises approximately 40% of total body weight and contains 50-75% of all body proteins. In general, muscle mass depends on the balance between protein synthesis and degradation and both processes are sensitive to factors such as nutritional status, hormonal balance, physical activity/exercise, and injury or disease, among others. In this review, we discuss the various domains of muscle structure and function including its cytoskeletal architecture, excitation-contraction coupling, energy metabolism, and force and power generation. We will limit the discussion to human skeletal muscle and emphasize recent scientific literature on single muscle fibers.
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            Estimation of skeletal muscle mass by bioelectrical impedance analysis.

            The purpose of this study was to develop and cross-validate predictive equations for estimating skeletal muscle (SM) mass using bioelectrical impedance analysis (BIA). Whole body SM mass, determined by magnetic resonance imaging, was compared with BIA measurements in a multiethnic sample of 388 men and women, aged 18-86 yr, at two different laboratories. Within each laboratory, equations for predicting SM mass from BIA measurements were derived using the data of the Caucasian subjects. These equations were then applied to the Caucasian subjects from the other laboratory to cross-validate the BIA method. Because the equations cross-validated (i.e., were not different), the data from both laboratories were pooled to generate the final regression equation SM mass (kg) = [(Ht 2 / R x 0.401) + (gender x 3.825) + (age x -0. 071)] + 5.102 where Ht is height in centimeters; R is BIA resistance in ohms; for gender, men = 1 and women = 0; and age is in years. The r(2) and SE of estimate of the regression equation were 0.86 and 2.7 kg (9%), respectively. The Caucasian-derived equation was applicable to Hispanics and African-Americans, but it underestimated SM mass in Asians. These results suggest that the BIA equation provides valid estimates of SM mass in healthy adults varying in age and adiposity.
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              119th ENMC international workshop: trial design in adult idiopathic inflammatory myopathies, with the exception of inclusion body myositis, 10-12 October 2003, Naarden, The Netherlands.

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                Author and article information

                Contributors
                yves.allenbach@aphp.fr
                Journal
                Brain Pathol
                Brain Pathol
                10.1111/(ISSN)1750-3639
                BPA
                Brain Pathology
                John Wiley and Sons Inc. (Hoboken )
                1015-6305
                1750-3639
                27 May 2021
                May 2021
                : 31
                : 3 ( doiID: 10.1111/bpa.v31.3 )
                : e12954
                Affiliations
                [ 1 ] Department of Internal Medicine and Clinical Immunlogy Sorbonne Université Pitié‐Salpêtrière University Hospital Paris France
                [ 2 ] Centre de Recherche en Myologie UMRS974 Association Institut de Myologie Institut National de la Santé et de la Recherche Médicale Sorbonne Université Paris France
                [ 3 ] Neuromuscular Physiology Laboratory Neuromuscular Investigation Center Institute of Myology Paris France
                [ 4 ] Department of Medical Imaging AP‐HP Hôpitaux Universitaires La Pitié Salpêtrière‐Charles‐Foix Sorbonne Université Paris France
                Author notes
                [*] [* ] Correspondence

                Yves Allenbach, Department of Internal Medicine and Clinical Immunlogy, Sorbonne Université, Pitié‐Salpêtrière University Hospital, Paris, France.

                Email: yves.allenbach@ 123456aphp.fr

                Author information
                https://orcid.org/0000-0003-0712-878X
                Article
                BPA12954
                10.1111/bpa.12954
                8412099
                34043260
                2df69a4c-98a7-478c-874c-5a6196bfec1d
                © 2021 The Authors. Brain Pathology published by John Wiley & Sons Ltd on behalf of International Society of Neuropathology.

                This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                : 22 February 2021
                : 11 March 2021
                Page count
                Figures: 5, Tables: 0, Pages: 16, Words: 12588
                Categories
                Mini‐symposium
                Mini‐symposium
                Custom metadata
                2.0
                May 2021
                Converter:WILEY_ML3GV2_TO_JATSPMC version:6.0.6 mode:remove_FC converted:31.08.2021

                Pathology
                idiopathic inflammatory myopathies,mri,ultra sound imaging
                Pathology
                idiopathic inflammatory myopathies, mri, ultra sound imaging

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