Fat Mobilization in Adipose Tissue of Weanling Rats with Hypothalamic Obesity

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Abstract

In vitro lipolysis (glycerol release), hormone-sensitive lipolytic activity and free fatty acid (FFA) release as well as the response of these parameters to adrenaline, were studied inadipose tissue of obese weanling rats with electrolytic lesions in the hypothalamic ventromedial nuclei (VMN). In the absence of adrenaline, adipose tissue from weanling VMN rats showed neither depressed lipolysis nor diminished lipolytic activity per mg of tissue protein, and esterification appeared to be equal to lipolysis since there was no FFA release. Adrenaline augmented lipolysis and hormone-sensitive lipolytic activity to the same extent in VMN as in control tissue, but produced an overall release of FFA which was significantly less in VMN than control. The lesser FFA release in the VMN tissue compared to control may be a result of greater utilization of FFA, by oxidation or for esterification, by that tissue when stimulated by adrenaline.

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Journal ID (publisher-id): HRE

Journal ID (nlm-ta): Horm Res Paediatr

Journal ID (doi): 10.1159/issn.1663-2818

Title: Hormone Research in Paediatrics

Publisher: S. Karger AG

ISSN (Print): 1663-2818

ISSN (Electronic): 1663-2826

Publication date Subscription-year: 1972

Publication date (Print): 1972

Publication date (Electronic): 21 November 2008

Volume: 3

Issue: 2

Pages: 97-104

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Departments of Medicine and Pathology, State University of New York at Buffalo, Buffalo, N.Y.

Article

Publisher ID: 178260 Other ID: Hormones 1972;3:97–104

DOI: 10.1159/000178260

SO-VID: 2e00c718-bc10-4f68-b6b2-c80aa4f75437

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Fat Mobilization in Adipose Tissue of Weanling Rats with Hypothalamic Obesity

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Karger: Endocrinology

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