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Nocathiacins, new thiazolyl peptide antibiotics from Nocardia sp. II. Isolation, characterization, and structure determination.
John E Leet
1 ,
Wenying Li ,
Helen A Ax ,
James A Matson ,
Stella Huang ,
Ron Huang ,
Joseph L Cantone ,
Dieter Drexler ,
Richard A Dalterio ,
Kin S Lam
Mar 2003
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Abstract
A new group of thiazolyl peptide antibiotics, the nocathiacins, was isolated from cultured broth of Nocardia sp. The major analogs nocathiacins I-III (1-3) were purified using silica gel and Sephadex LH-20 chromatography techniques. The structures of nocathiacins I-III were determined by spectroscopic (2D-NMR, MSn) methods, and share structural similarities to glycothiohexide-alpha (4).