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      In vivo evaluation of posterior eye elasticity using shaker-based optical coherence elastography

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          Abstract

          Age-related macular degeneration (AMD) is a progressive retinal disease and becomes the leading cause of blindness. It is well established that early detection is the key to preservation of functional vision. However, it is very difficult to diagnose AMD in very early stages, before structural changes are evident. Consequently, investigating the biomechanical properties of the retina maybe essential for understanding its physiological function. In this study, we present a shear wave-based quantitative method for estimating the elasticity of the posterior eye using shaker-based optical coherence elastography. This technique has been developed and validated on both a homogeneous phantom and a healthy rabbit in vivo. The shear wave speed from the ganglion side to the photoreceptor side of the rabbit eye is 4.1 m/s, 4.9 m/s, and 6.7 m/s, respectively. In addition, the most stiff sclera region has an average shear wave speed of 9.1 m/s. The results demonstrate the feasibility of using this technique to quantify biomechanical properties of the posterior eye and its potential translation to the clinical study.

          Impact statement

          Herein, we propose a potentially clinical applicable shaker-based optical coherence elastography (OCE) technique to characterize the biomechanical properties of the posterior eye, including different layers of the retina. Compared with either acoustic radiation force OCE or air-puff OCE, the newly developed method can induce sufficient shear wave propagation at the posterior eye with high resolution and large field of view.

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          Author and article information

          Journal
          Exp Biol Med (Maywood)
          Exp. Biol. Med. (Maywood)
          EBM
          spebm
          Experimental Biology and Medicine
          SAGE Publications (Sage UK: London, England )
          1535-3702
          1535-3699
          7 January 2020
          February 2020
          : 245
          : 4 , Thematic Issue Biomedical Optical Imaging Technology and Applications Editor: Shuliang Jiao
          : 282-288
          Affiliations
          [1 ]Department of Biomedical Engineering and NIH Ultrasonic Transducer Resource Center, University of Southern California, Los Angeles, CA 90089, USA
          [2 ]USC Roski Eye Institute, University of Southern California, Los Angeles, CA 90033, USA
          [3 ]Beckman Laser Institute, University of California, Irvine, Irvine, CA 92612, USA
          Author notes
          [*]

          These authors contributed equally to this work.

          [*]Zhongping Chen. Email: z2chen@ 123456uci.edu ; Qifa Zhou. Email: qifazhou@ 123456usc.edu
          Author information
          https://orcid.org/0000-0003-3634-8757
          Article
          PMC7370597 PMC7370597 7370597 10.1177_1535370219897617
          10.1177/1535370219897617
          7370597
          31910651
          2e6261cb-a2b9-4cdb-ac80-d3cae04de5db
          © 2020 by the Society for Experimental Biology and Medicine
          History
          : 16 September 2019
          : 29 October 2019
          Funding
          Funded by: National Institutes of Health, FundRef https://doi.org/10.13039/100000002;
          Award ID: P30EY029220
          Award ID: R01CA211602
          Award ID: R01EY026091
          Award ID: R01EY028662
          Award ID: R01EY030126
          Categories
          Original Research
          Custom metadata
          ts2

          posterior eye elasticity,optical coherence tomography,Shear wave elastography

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