Measurement of Lipoprotein-Associated Phospholipase A2 by Use of 3 Different Methods: Exploration of Discordance between ELISA and Activity Assays.

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Abstract

Lipoprotein-associated phospholipase A2 (Lp-PLA2), an enzyme associated with inflammation, is used as a biomarker for cardiovascular disease risk. Both the concentration and activity of Lp-PLA2 have been shown to be clinically relevant. However, there is a discordance between the serum concentration of Lp-PLA2 measured by the standard ELISA-based immunoassays and the activity of this enzyme, leading to substantial discordance in risk categorization depending on assay format.

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Journal

Journal ID (iso-abbrev): Clin Chem

Title: Clinical chemistry

Publisher: American Association for Clinical Chemistry (AACC)

ISSN (Electronic): 1530-8561

ISSN (Print): 0009-9147

Publication date (Electronic): April 2018

Volume: 64

Issue: 4

Affiliations

[1 ] Cleveland HeartLab, Cleveland, OH.

[2 ] SISCAPA Assay Technologies, Inc., Washington, DC.

[3 ] Cleveland HeartLab, Cleveland, OH; cbystrom@clevelandheartlab.com.

Article

Publisher Item ID: clinchem.2017.279752

DOI: 10.1373/clinchem.2017.279752

PubMed ID: 29321128

SO-VID: 2f6ed744-df41-433a-9bdf-02fc5b5bcc9e

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