3
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Microfluidic Actuated and Controlled Systems and Application for Lab-on-Chip in Space Life Science

      Read this article at

      ScienceOpenPublisher
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The use of space environment to carry out life science research is of great significance. However, there are limitations in complex manipulation, research models based on mammalian and 2-dimensional cell culture experiments, etc. Microfluidic chips possess the characteristics of integrating the relevant functions of traditional laboratories into micron-scale chips, with low energy consumption, high throughput, and automation. The application of microfluidic chips can overcome the challenges of space environments, the scarce experimental resources, and the unmanned operation problems to some extent. Moreover, microfluidic chips can realize long-term experimental operation and remote data recording and transmission. To carry out related research with microfluidic chips, the actuation and control of microfluidics are very important. In this paper, the microfluidic actuated and controlled technologies in microfluidic chips are reviewed, and then the application of microfluidic chips and microfluidic actuated and controlled systems in space life science is also briefly described.

          Related collections

          Most cited references144

          • Record: found
          • Abstract: not found
          • Article: not found

          RESISTANCE OF SOLID SURFACES TO WETTING BY WATER

            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Organs-on-chips: into the next decade

            Organs-on-chips (OoCs), also known as microphysiological systems or 'tissue chips' (the terms are synonymous), have attracted substantial interest in recent years owing to their potential to be informative at multiple stages of the drug discovery and development process. These innovative devices could provide insights into normal human organ function and disease pathophysiology, as well as more accurately predict the safety and efficacy of investigational drugs in humans. Therefore, they are likely to become useful additions to traditional preclinical cell culture methods and in vivo animal studies in the near term, and in some cases replacements for them in the longer term. In the past decade, the OoC field has seen dramatic advances in the sophistication of biology and engineering, in the demonstration of physiological relevance and in the range of applications. These advances have also revealed new challenges and opportunities, and expertise from multiple biomedical and engineering fields will be needed to fully realize the promise of OoCs for fundamental and translational applications. This Review provides a snapshot of this fast-evolving technology, discusses current applications and caveats for their implementation, and offers suggestions for directions in the next decade.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Surface acoustic wave microfluidics.

              The recent introduction of surface acoustic wave (SAW) technology onto lab-on-a-chip platforms has opened a new frontier in microfluidics. The advantages provided by such SAW microfluidics are numerous: simple fabrication, high biocompatibility, fast fluid actuation, versatility, compact and inexpensive devices and accessories, contact-free particle manipulation, and compatibility with other microfluidic components. We believe that these advantages enable SAW microfluidics to play a significant role in a variety of applications in biology, chemistry, engineering and medicine. In this review article, we discuss the theory underpinning SAWs and their interactions with particles and the contacting fluids in which they are suspended. We then review the SAW-enabled microfluidic devices demonstrated to date, starting with devices that accomplish fluid mixing and transport through the use of travelling SAW; we follow that by reviewing the more recent innovations achieved with standing SAW that enable such actions as particle/cell focusing, sorting and patterning. Finally, we look forward and appraise where the discipline of SAW microfluidics could go next.
                Bookmark

                Author and article information

                Journal
                Space: Science & Technology
                Space Sci Technol
                American Association for the Advancement of Science (AAAS)
                2692-7659
                January 2023
                January 2023
                : 3
                Affiliations
                [1 ]Beijing Key Laboratory for Separation and Analysis in Biomedicine and Pharmaceuticals, School of Life Science, Beijing Institute of Technology, Beijing 100081, China.
                Article
                10.34133/space.0008
                2f952a57-853c-4da4-a267-d764c5c70063
                © 2023
                History

                Comments

                Comment on this article