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      Compensation System for Biomagnetic Measurements with Optically Pumped Magnetometers inside a Magnetically Shielded Room

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          Abstract

          Magnetography with superconducting quantum interference device (SQUID) sensor arrays is a well-established technique for measuring subtle magnetic fields generated by physiological phenomena in the human body. Unfortunately, the SQUID-based systems have some limitations related to the need to cool them down with liquid helium. The room-temperature alternatives for SQUIDs are optically pumped magnetometers (OPM) operating in spin exchange relaxation-free (SERF) regime, which require a very low ambient magnetic field. The most common two-layer magnetically shielded rooms (MSR) with residual magnetic field of 50 nT may not be sufficiently magnetically attenuated and additional compensation of external magnetic field is required. A cost-efficient compensation system based on square Helmholtz coils was designed and successfully used for preliminary measurements with commercially available zero-field OPM. The presented setup can reduce the static ambient magnetic field inside a magnetically shielded room, which improves the usability of OPMs by providing a proper environment for them to operate, independent of initial conditions in MSR.

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          Most cited references50

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          Moving magnetoencephalography towards real-world applications with a wearable system

          Summary Imaging human brain function with techniques such as magnetoencephalography1 (MEG) typically requires a subject to perform tasks whilst their head remains still within a restrictive scanner. This artificial environment makes the technique inaccessible to many people, and limits the experimental questions that can be addressed. For example, it has been difficult to apply neuroimaging to investigation of the neural substrates of cognitive development in babies and children, or in adult studies that require unconstrained head movement (e.g. spatial navigation). Here, we develop a new type of MEG system that can be worn like a helmet, allowing free and natural movement during scanning. This is possible due to the integration of new quantum sensors2,3 that do not rely on superconducting technology, with a novel system for nulling background magnetic fields. We demonstrate human electrophysiological measurement at millisecond resolution whilst subjects make natural movements, including head nodding, stretching, drinking and playing a ball game. Results compare well to the current state-of-the-art, even when subjects make large head movements. The system opens up new possibilities for scanning any subject or patient group, with myriad applications such as characterisation of the neurodevelopmental connectome, imaging subjects moving naturally in a virtual environment, and understanding the pathophysiology of movement disorders.
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            Magnetoencephalography: evidence of magnetic fields produced by alpha-rhythm currents.

            D. Cohen (1968)
            Weak alternating magnetic fields outside the human scalp, produced by alpha-rhythm currents, are demonstrated. Subject ard magnetic detector were housed in a multilayer magnetically shielded chamber. Background magnetic noise was reduced by signal-averaging. The fields near the scalp are about 1 x 10(-9) gauss (peak to peak). A course distribution shows left-right symmetry for the particular averaging technique used here.
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              Magnetoencephalography: detection of the brain's electrical activity with a superconducting magnetometer.

              Measurements of the brain's magnetic field, called magnetoencephalograms (MEG's), have been taken with a superconducting magnetometer in a heavily shielded room. This magnetometer has been adjusted to a much higher sensitivity than was previously attainable, and as a result MEG's can, for the first time, be taken directly, without noise averaging. MEG's are shown, simultaneously with the electroencephalogram (EEG), of the alpha rhythm of a normal subject and of the slow waves from an abnormal subject. The normal MEG shows the alpha rhythm, as does the EEG, when the subject's eyes are closed; however, this MEG also shows that higher detector sensitivity, by a factor of 3, would be necessary in order to clearly show the smaller brain events when the eyes are open. The abnormal MEG, including a measurenment of the direct-current component, suggests that the MEG may yield some information which is new and different from that provided by the EEG.
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                Author and article information

                Journal
                Sensors (Basel)
                Sensors (Basel)
                sensors
                Sensors (Basel, Switzerland)
                MDPI
                1424-8220
                14 August 2020
                August 2020
                : 20
                : 16
                : 4563
                Affiliations
                Warsaw University of Technology, Faculty of Mechatronics, Institute of Metrology and Biomedical Engineering, Boboli 8 St, 02-525 Warsaw, Poland; krzysztof.wildner@ 123456pw.edu.pl (K.W.); tadeusz.palko@ 123456pw.edu.pl (T.P.); michal.wladzinski@ 123456pw.edu.pl (M.W.)
                Author notes
                Author information
                https://orcid.org/0000-0001-5856-2872
                https://orcid.org/0000-0003-0531-8563
                https://orcid.org/0000-0001-8185-8700
                https://orcid.org/0000-0002-6986-251X
                Article
                sensors-20-04563
                10.3390/s20164563
                7471992
                32823964
                309cb20f-ea06-4140-a49a-147270ff7305
                © 2020 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 30 June 2020
                : 12 August 2020
                Categories
                Letter

                Biomedical engineering
                optically pumped magnetometer,magnetically shielded room,helmholtz coils,biomagnetism

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