0
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      The alliance of sphingosine-1-phosphate and its receptors in immunity.

      Nature reviews. Immunology

      Animals, Cell Movement, Chemotaxis, Dendritic Cells, immunology, metabolism, Humans, Lymphocytes, Lysophospholipids, Macrophages, Mast Cells, Receptors, Lysosphingolipid, Signal Transduction, Sphingosine, analogs & derivatives

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Sphingosine-1-phosphate (S1P) is a biologically active metabolite of plasma-membrane sphingolipids that is essential for immune-cell trafficking. Its concentration is increased in many inflammatory conditions, such as asthma and autoimmunity. Much of the immune function of S1P results from the engagement of a family of G-protein-coupled receptors (S1PR1-S1PR5). Recent findings on the role of S1P in immunosurveillance, the discovery of regulatory mechanisms in S1P-mediated immune-cell trafficking and new advances in understanding the mechanism by which S1P affects immune-cell function indicate that the alliance between S1P and its receptors has a fundamental role in immunity.

          Related collections

          Author and article information

          Journal
          18787560
          2600775
          10.1038/nri2400

          Comments

          Comment on this article