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      1. Lumbosacral radicular pain

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          Abstract

          Introduction

          Patients suffering lumbosacral radicular pain report radiating pain in one or more lumbar or sacral dermatomes. In the general population, low back pain with leg pain extending below the knee has an annual prevalence that varies from 9.9% to 25%.

          Methods

          The literature on the diagnosis and treatment of lumbosacral radicular pain was reviewed and summarized.

          Results

          Although a patient's history, the pain distribution pattern, and clinical examination may yield a presumptive diagnosis of lumbosacral radicular pain, additional clinical tests may be required. Medical imaging studies can demonstrate or exclude specific underlying pathologies and identify nerve root irritation, while selective diagnostic nerve root blocks can be used to confirm the affected level(s).

          In subacute lumbosacral radicular pain, transforaminal corticosteroid administration provides short‐term pain relief and improves mobility. In chronic lumbosacral radicular pain, pulsed radiofrequency (PRF) treatment adjacent to the spinal ganglion (DRG) can provide pain relief for a longer period in well‐selected patients. In cases of refractory pain, epidural adhesiolysis and spinal cord stimulation can be considered in experienced centers.

          Conclusions

          The diagnosis of lumbosacral radicular pain is based on a combination of history, clinical examination, and additional investigations. Epidural steroids can be considered for subacute lumbosacral radicular pain. In chronic lumbosacral radicular pain, PRF adjacent to the DRG is recommended. SCS and epidural adhesiolysis can be considered for cases of refractory pain in specialized centers.

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          Most cited references247

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          What low back pain is and why we need to pay attention

          Low back pain is a very common symptom. It occurs in high-income, middle-income, and low-income countries and all age groups from children to the elderly population. Globally, years lived with disability caused by low back pain increased by 54% between 1990 and 2015, mainly because of population increase and ageing, with the biggest increase seen in low-income and middle-income countries. Low back pain is now the leading cause of disability worldwide. For nearly all people with low back pain, it is not possible to identify a specific nociceptive cause. Only a small proportion of people have a well understood pathological cause-eg, a vertebral fracture, malignancy, or infection. People with physically demanding jobs, physical and mental comorbidities, smokers, and obese individuals are at greatest risk of reporting low back pain. Disabling low back pain is over-represented among people with low socioeconomic status. Most people with new episodes of low back pain recover quickly; however, recurrence is common and in a small proportion of people, low back pain becomes persistent and disabling. Initial high pain intensity, psychological distress, and accompanying pain at multiple body sites increases the risk of persistent disabling low back pain. Increasing evidence shows that central pain-modulating mechanisms and pain cognitions have important roles in the development of persistent disabling low back pain. Cost, health-care use, and disability from low back pain vary substantially between countries and are influenced by local culture and social systems, as well as by beliefs about cause and effect. Disability and costs attributed to low back pain are projected to increase in coming decades, in particular in low-income and middle-income countries, where health and other systems are often fragile and not equipped to cope with this growing burden. Intensified research efforts and global initiatives are clearly needed to address the burden of low back pain as a public health problem.
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            Pain Mechanisms: A New Theory

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              A consensus approach toward the standardization of back pain definitions for use in prevalence studies.

              A modified Delphi study conducted with 28 experts in back pain research from 12 countries. To identify standardized definitions of low back pain that could be consistently used by investigators in prevalence studies to provide comparable data. Differences in the definition of back pain prevalence in population studies lead to heterogeneity in study findings, and limitations or impossibilities in comparing or summarizing prevalence figures from different studies. Back pain definitions were identified from 51 articles reporting population-based prevalence studies, and dissected into 77 items documenting 7 elements. These items were submitted to a panel of experts for rating and reduction, in 3 rounds (participation: 76%). Preliminary results were presented and discussed during the Amsterdam Forum VIII for Primary Care Research on Low Back Pain, compared with scientific evidence and confirmed and fine-tuned by the panel in a fourth round and the preparation of the current article. Two definitions were agreed on a minimal definition (with 1 question covering site of low back pain, symptoms observed, and time frame of the measure, and a second question on severity of low back pain) and an optimal definition that is made from the minimal definition and add-ons (covering frequency and duration of symptoms, an additional measure of severity, sciatica, and exclusions) that can be adapted to different needs. These definitions provide standards that may improve future comparisons of low back pain prevalence figures by person, place and time characteristics, and offer opportunities for statistical summaries.
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                Author and article information

                Contributors
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                Journal
                Pain Practice
                Pain Practice
                Wiley
                1530-7085
                1533-2500
                November 20 2023
                Affiliations
                [1 ] Department of Anesthesiology, Intensive Care, Emergency Medicine and Multidisciplinary Pain Center Ziekenhuis Oost‐Limburg Genk/Lanaken Belgium
                [2 ] Pain Medicine Division, Department of Anesthesiology Johns Hopkins School of Medicine Baltimore Maryland USA
                [3 ] Department of Anesthesiology and Pain Medicine Rijnstate Ziekenhuis Velp The Netherlands
                [4 ] Anesthesiology and Pain Medicine Amsterdam University Medical Centers Amsterdam The Netherlands
                [5 ] Department of Anesthesiology UMCG Pain Center Groningen University of Groningen Groningen The Netherlands
                [6 ] Department of Anesthesiology and Pain Medicine Erasmusmc Rotterdam The Netherlands
                [7 ] Department of Anesthesiology and Pain Medicine University Medical Center Utrecht Utrecht The Netherlands
                [8 ] Department of Anesthesiology and Pain Medicine Catharina Ziekenhuis Eindhoven The Netherlands
                [9 ] Department of Anesthesiology, Pain and Palliative Medicine Radboud University Nijmegen The Netherlands
                [10 ] Department of Anesthesiology and Pain Medicine Brigham & Women's Spine Center Boston Massachusetts USA
                [11 ] Department of Anesthesiology and Pain Medicine Maastricht University Medical Center Maastricht The Netherlands
                Article
                10.1111/papr.13317
                30dd719b-d439-4779-ae99-3f1d4cdd2f13
                © 2023

                http://creativecommons.org/licenses/by-nc/4.0/

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