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      Pediatric hydatidosis in the south-east of the Buenos Aires province, Argentina Translated title: Hidatidosis pediátrica en el sudeste de la provincia de Buenos Aires, Argentina

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          Abstract

          Hydatidosis is a zoonosis produced by the metacestode Echinococcus spp. The aims of this research are: to contribute to the knowledge of pediatric hydatidosis in the south-east of Buenos Aires province, to study its evolution from 1993 to 2002 at the Regional Maternity and Pediatric Hospital "Dr. Victorio Tetamanti", to determine the strains involved and to discuss the importance of the disease. The clinical records of diagnosed and/or operated patients were reviewed with regard to the hydatid disease. The strain was determined by using PCRs with Eg1 121a/122a primers. Forty-four cases were analyzed. Fifty nine point one per cent of the patients were boys. The mean age was 8 SD=3.8 years. Sixty one point four per cent had urban residence. Ultrasonography was used in 61% of the cases. The hepatic location was most frequently seen and the liver/lung ratio was 1.25. Ninety point nine per cent of patients received surgical treatment. Albendazole was used in 52% of cases. The average hospitalization time was 11 days. The Gl/G2 strain group was determined. This report is the first one of its kind in the studied region. The permanence of hydatidosis in the region depends on the natural transmission of the parasite in the absence of control and prevention measures. The health authorities should implement strategies of prevention and control in the study area.

          Translated abstract

          Los objetivos de este trabajo fueron: contribuir al conocimiento de la hidatidosis pediátrica en el sudeste de la provincia de Buenos Aires, estudiar su evolución desde 1993 hasta 2002, establecer la o las cepas involucradas y discutir la importancia de la enfermedad. Para ello se revisaron las historias clínicas de los pacientes pediátricos con diagnóstico de hidatidosis asistidos en el Hospital Interzonal Especializado Materno Infantil "Dr. Victorio Tetamanti" durante ese período. Se analizaron 44 casos, el 59,1% de ellos correspondió a varones. La media de edad fue de 8 años (SD=3,8 años) y el 61,4% de los niños afectados eran de residencia urbana. Se empleó ultrasonografía como método diagnóstico en el 61% de los casos. La localización hepática fue la más frecuente y la relación hígado/pulmón fue 1,25. El 90,9% recibió tratamiento quirúrgico. Se utilizó albendazol en el 52% de los pacientes. El tiempo de hospitalización tuvo una mediana de 11 días. Las cepas se determinaron mediante PCR con los cebadores Eg1 121a/122a. Se determinó la presencia de cepas del grupo G1/G2, dato informado por primera vez en humanos para la región de estudio. Se concluyó que la permanencia de la enfermedad en la región depende de la transmisión natural del parásito en ausencia de medidas de control y prevención. Por consiguiente, las autoridades de salud deberían implementar estrategias de prevención y control en dicha zona.

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          Most cited references37

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          Biological, Epidemiological, and Clinical Aspects of Echinococcosis, a Zoonosis of Increasing Concern

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            Towards a taxonomic revision of the genus Echinococcus.

            Echinococcus remains a significant public health problem worldwide and, in several regions, the aetiological agents of cystic hydatid disease/echinococcosis are extending their range. The taxonomy of Echinococcus has been a controversial issue for decades, but the outcome of recent molecular epidemiological studies has served to reinforce proposals made ten years ago to revise the taxonomy of Echinococcus. A formal nomenclature is essential for effective communication, and provides the stability that underpins epidemiological investigations. It will also serve to recognize the contribution of early taxonomists.
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              Molecular genetic characterization of the Fennoscandian cervid strain, a new genotypic group (G10) of Echinococcus granulosus.

              The northern biotype of Echinococcus granulosus occurs in North America and northern Eurasia in life-cycles involving cervids. Previously, cervid isolates of E. granulosus from North America have been characterized using molecular genetic techniques as the G8 genotype. In this study, 5 isolates of E. granulosus were collected from 4 reindeer and 1 moose in north-eastern Finland. DNA sequences within regions of mitochondrial cytochrome c oxidase I (COI) and NADH dehydrogenase I (NI)I) genes and the internal transcribed spacer 1 (ITS-1) fragment of the ribosomal DNA were analysed. The mitochondrial nucleotide sequences were identical in all isolates, but high sequence variation was found in the ITS-1 region. Mitochondrial and nuclear sequences of the Finnish cervid E. granulosus and the camel strain (G6) of E. granulosus resembled closely each other. According to phylogenetic analyses, the Finnish isolates have close relationships also with the pig (G7) and cattle (G5) strains. Although some similarities were found with the previously published North American cervid strain (G8), particularly in the NDI sequence and some of the ITS-1 clones, the Finnish E. granulosus form represents a distinct, previously undescribed genotype of E. granulosus. The novel genotype is hereby named as the Fennoscandian cervid strain (G10).
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                Author and article information

                Journal
                ram
                Revista argentina de microbiología
                Rev. argent. microbiol.
                Asociación Argentina de Microbiología (Ciudad Autónoma de Buenos Aires, , Argentina )
                0325-7541
                1851-7617
                June 2009
                : 41
                : 2
                : 105-111
                Affiliations
                [01] Mar del Plata Buenos Aires orgnameUniversidad Nacional de Mar del Plata orgdiv1Facultad de Ciencias Exactas y Naturales orgdiv2Departamento de Biología
                [02] orgnameConsejo Nacional de Investigaciones Científicas y Técnicas
                [04] Ciudad Autónoma de Buenos Aires orgnameANLIS Dr. Carlos G. Malbrán orgdiv1INEI orgdiv2Departamento de Parasitología Argentina
                [03] Mar del Plata orgnameHospital Interzonal Especializado Materno Infantil Dr. Victorio Tetamanti orgdiv1Servicio de Infectología
                Article
                S0325-75412009000200009 S0325-7541(09)04100200009
                311c9703-e729-4cff-9f04-d9055b81d93b

                This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

                History
                : 29 July 2008
                : 31 March 2009
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 39, Pages: 7
                Product

                SciELO Argentina

                Categories
                Clinical Microbiology and Infectious Diseases

                Pediatric hydatidosis,Echinococcus granulosus,Epidemiology,Zoonoses,Argentina,Hidatidosis pediátrica,Epidemiología,Zoonosis

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