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Abstract
A 54-year-old woman from Wuhan, China, the epicenter of the COVID-19 (formerly known
as 2019 novel coronavirus [2019-nCoV]) outbreak (1,2), presented with a 2-day history
of fever. The physical examination revealed a temperature of 39.0°C, and laboratory
studies showed normal leukocyte with a differential of 82.8% neutrophils, 9.5% lymphocytes,
and 0.1% eosinophils. Screening for multiple respiratory pathogens, including influenza
A, influenza B, respiratory syncytial virus, adenovirus, human parainfluenza virus,
Mycoplasma pneumoniae, and Chlamydia pneumoniae was negative. At presentation, nonenhanced
chest CT showed multifocal nodular opacities in multiple lobes (Fig 1a). After 6 days
of supportive treatment, follow-up CT showed decreased density of the opacities and
development of ground glass and reversed halo sign (Fig 1b). The initial nasopharyngeal
swab test for the COVID-19 nucleic acids had been negative, but a second test confirmed
infection. After 3 days of treatment with oseltamivir, follow-up CT showed significant
improvement in the extent and density of the ground-glass opacities (Fig 1c).
A 54-year-old woman who presented with fever. (a) Axial thin-section unenhanced CT
images showed multifocal nodular opacities with peribronchial and subpleural distribution
(arrows) in both lungs on day 2 of symptoms. (b) Follow-up CT on day 8 showed newly
developed ground-glass opacities (arrowheads) and decreasing density of the nodular
opacities, with reversed halo sign (arrows). (c) Last follow-up CT on day 11, 3 days
after initiation of antiviral treatment, showed significantly improvement of the ground-glass
opacities.
A 54-year-old woman who presented with fever. (a) Axial thin-section unenhanced CT
images showed multifocal nodular opacities with peribronchial and subpleural distribution
(arrows) in both lungs on day 2 of symptoms. (b) Follow-up CT on day 8 showed newly
developed ground-glass opacities (arrowheads) and decreasing density of the nodular
opacities, with reversed halo sign (arrows). (c) Last follow-up CT on day 11, 3 days
after initiation of antiviral treatment, showed significantly improvement of the ground-glass
opacities.
A 54-year-old woman who presented with fever. (a) Axial thin-section unenhanced CT
images showed multifocal nodular opacities with peribronchial and subpleural distribution
(arrows) in both lungs on day 2 of symptoms. (b) Follow-up CT on day 8 showed newly
developed ground-glass opacities (arrowheads) and decreasing density of the nodular
opacities, with reversed halo sign (arrows). (c) Last follow-up CT on day 11, 3 days
after initiation of antiviral treatment, showed significantly improvement of the ground-glass
opacities.
Journal ID (iso-abbrev): Radiol Cardiothorac Imaging
Journal ID (publisher-id): cardiothoracic
Title:
Radiology. Cardiothoracic Imaging
Publisher:
Radiological Society of North America
ISSN
(Electronic):
2638-6135
Publication date
(Electronic):
14
February
2020
Volume: 2
Issue: 1
Electronic Location Identifier: e200031
Affiliations
[1]From the Department of Radiology, Central Hospital of Wuhan, Tongji Medical College,
Huazhong University of Science and Technology, Wuhan, 430014, China
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