Diagnosis of Hemoglobinopathy and β-Thalassemia by 21 Tesla Fourier Transform Ion Cyclotron Resonance Mass Spectrometry and Tandem Mass Spectrometry of Hemoglobin from Blood.

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Abstract

Hemoglobinopathies and thalassemias are the most common genetically determined disorders. Current screening methods include cation-exchange HPLC and electrophoresis, the results of which can be ambiguous because of limited resolving power. Subsequently, laborious genetic testing is required for confirmation.

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Author and article information

Journal

Journal ID (iso-abbrev): Clin Chem

Title: Clinical chemistry

Publisher: American Association for Clinical Chemistry (AACC)

ISSN (Electronic): 1530-8561

ISSN (Print): 0009-9147

Publication date (Electronic): Aug 2019

Volume: 65

Issue: 8

Affiliations

[1 ] Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL.

[2 ] Rockwood Scientific Consulting, Salt Lake City, UT.

[3 ] University of Utah Health, Salt Lake City, UT.

[4 ] ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT.

[5 ] National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL.

[6 ] Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL; marshall@magnet.fsu.edu.

Article

Publisher Item ID: clinchem.2018.295766

DOI: 10.1373/clinchem.2018.295766

PubMed ID: 31040099

SO-VID: 331bf4af-6540-4df4-b5bf-8e40a4dc1297

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