Azilsartan improves glycemic status and reduces kidney damage in zucker diabetic fatty rats.

Hye Khan, Md Abdul; Neckar, Jan; Haines, Jasmine; Imig, John D.

doi:10.1093/ajh/hpu016

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Azilsartan improves glycemic status and reduces kidney damage in zucker diabetic fatty rats.

Author(s): Md Abdul Hye Khan ¹ , Jan Neckář ² , Jasmine Haines ¹ , John D Imig ³

Publication date (Electronic): Aug 2014

Journal: American journal of hypertension

Publisher: Oxford University Press (OUP)

Keywords: azilsartan medoxomil, blood pressure, hypertension, inflammation, kidney injury, oxidative stress, type 2 diabetes.

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Abstract

Azilsartan medoxomil (AZL-M), an angiotensin II receptor blocker, demonstrates antihypertensive and organ protective effects in hypertension. We investigated the efficacy of AZL-M to ameliorate metabolic syndrome and kidney damage associated with type 2 diabetes using Zucker diabetic fatty (ZDF) rats.

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Journal ID (iso-abbrev): Am. J. Hypertens.

Title: American journal of hypertension

Publisher: Oxford University Press (OUP)

ISSN (Electronic): 1941-7225

ISSN (Print): 0895-7061

Publication date (Electronic): Aug 2014

Volume: 27

Issue: 8

Affiliations

[1 ] Department of Pharmacology & Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin;

[2 ] Department of Pharmacology & Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin; Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic;

[3 ] Department of Pharmacology & Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin; Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin. jdimig@mcw.edu.

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Publisher Item ID: hpu016

DOI: 10.1093/ajh/hpu016

PubMed ID: 24598210

SO-VID: 33464664-fc1a-4f0c-8d5d-29859749d112

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Keywords: azilsartan medoxomil,blood pressure,hypertension,inflammation,kidney injury,oxidative stress,type 2 diabetes.

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Keywords: azilsartan medoxomil, blood pressure, hypertension, inflammation, kidney injury, oxidative stress, type 2 diabetes.

Azilsartan improves glycemic status and reduces kidney damage in zucker diabetic fatty rats.

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Karger: Nephrology

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