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      Accuracy of follicle count and ovulation confirmation using magnetic resonance imaging in microminipigs with normal estrus cycles

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          Abstract

          Magnetic resonance imaging (MRI) is suggested to be useful for counting follicles and confirming ovulation in microminipigs. However, its accuracy is unknown. We have compared the number of follicles counted by MRI to that of corpus hemorrhagicum confirmed directly by visual inspection. The follicles of 17 microminipigs were counted by using ovarian MRI on a 0.4 Tesla MRI System every 24 hr after estrus until follicle images disappeared. Then, we performed laparotomy to count their corpus hemorrhagicum. Significant correlation was observed between follicle counts obtained using MRI (5.18 ± 1.78 per head) and the numbers of corpus hemorrhagicum (5.47 ± 1.74 per head). In conclusion, follicle counts using 0.4-T MRI were reliable, and confirmed microminipig ovulation.

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          The miniature pig as an animal model in biomedical research.

          Barbora Dvořánková, Karel Smetana, Jitka Ourednik … (2005)
          Crucial prerequisites for the development of safe preclinical protocols in biomedical research are suitable animal models that would allow for human-related validation of valuable research information gathered from experimentation with lower mammals. In this sense, the miniature pig, sharing many physiological similarities with humans, offers several breeding and handling advantages (when compared to non-human primates), making it an optimal species for preclinical experimentation. The present review offers several examples taken from current research in the hope of convincing the reader that the porcine animal model has gained massively in importance in biomedical research during the last few years. The adduced examples are taken from the following fields of investigation: (a) the physiology of reproduction, where pig oocytes are being used to study chromosomal abnormalities (aneuploidy) in the adult human oocyte; (b) the generation of suitable organs for xenotransplantation using transgene expression in pig tissues; (c) the skin physiology and the treatment of skin defects using cell therapy-based approaches that take advantage of similarities between pig and human epidermis; and (d) neurotransplantation using porcine neural stem cells grafted into inbred miniature pigs as an alternative model to non-human primates xenografted with human cells.
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            Microminipig, a non-rodent experimental animal optimized for life science research: preface.

            NAOKI KANEKO, Atsushi Sugiyama, Yasukatsu Izumi … (2010)
            Fuji Micra Inc. has recently achieved success in a challenging and prospective project that produces the smallest pig in the world, the "Microminipig", at a breeding farm at the foothills of Mt. Fuji in Japan. Microminipigs weigh approximately 7.0 kg at 6 months of age when they are mature. Microminipigs have been provided to several research organizations in Japan as a non-rodent experimental animal optimized for life science research.
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              Body and major organ sizes of young mature microminipigs determined by computed tomography.

              Masaki TAKASU, Eriko Tsuji, Noriaki Imaeda … (2015)
              To understand the anatomical characteristics of microminipigs, one of the smallest miniature pigs, as a large animal model, we measured the body and organ sizes of four-, five-, six-, and seven-month-old microminipigs (n = 4, females) using computed tomography. In addition, the results were compared with those of young mature beagles (10 months old, two males and three females), which have been widely used as a large animal model. The microminipigs at 4-6 months of age were much smaller than the beagles. However, when the microminipigs reached seven months of age, their overall size was similar to that of the beagles. The thoracic cavity volume of the seven-month-old microminipigs was less than half that of the beagles, and the cavity was largely filled by the heart. The liver size of the seven-month-old microminipigs was approximately half of that of the beagles. Moreover, the spleen of the seven-month-old microminipigs was different in morphology, but not different in size from that of the beagles. In addition, although their volumes were the same, the kidneys of the seven-month-old microminipigs, unlike those of the beagles, were flattened in shape. Collectively, the major abdominal organs of the seven-month-old microminipigs were either the same size or smaller than those of the beagles, but the abdominal cavity volume of the seven-month-old microminipigs was larger than that of the beagles. Thus, the abdominal cavity of microminipigs is assumed to be filled with the gastrointestinal tract. The anatomical characteristics of the young mature microminipigs revealed in our study suggest that microminipigs could have great potential as a large animal model for biomedical research.
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                Author and article information

                Journal
                Journal ID (nlm-ta): J Vet Med Sci
                Journal ID (iso-abbrev): J. Vet. Med. Sci
                Journal ID (publisher-id): JVMS
                Title: The Journal of Veterinary Medical Science
                Publisher: The Japanese Society of Veterinary Science
                ISSN (Print): 0916-7250
                ISSN (Electronic): 1347-7439
                Publication date (Electronic): 28 November 2017
                Publication date (Print): January 2018
                Volume: 80
                Issue: 1
                Pages: 125-127
                Affiliations
                [1) ]Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan
                [2) ]Education Center for Food Animal Health (GeFAH), Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan
                Author notes
                [* ]Correspondence to: Takasu, M.: takasu@ 123456gifu-u.ac.jp
                Article
                Publisher ID: 17-0417
                DOI: 10.1292/jvms.17-0417
                PMC ID: 5797870
                PubMed ID: 29187696
                SO-VID: 34ae255a-1ece-44ca-8c72-cf3a5f766720
                Copyright © ©2018 The Japanese Society of Veterinary Science
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/ )

                History
                Date received : 28 July 2017
                Date accepted : 31 October 2017
                Categories
                Subject: Theriogenology
                Subject: Note

                Keywords: follicle count,magnetic resonance imaging,microminipigs,ovulation confirmation
                Data availability:
                Keywords: follicle count, magnetic resonance imaging, microminipigs, ovulation confirmation

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