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      Role of interleukin-1β during pain and inflammation

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      Brain Research Reviews

      Elsevier BV

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          Abstract

          The cytokine cascade in pain and inflammatory processes is a tremendously complex system, involving glial, immune, and neuronal cell interactions. IL-1beta is a pro-inflammatory cytokine that has been implicated in pain, inflammation and autoimmune conditions. This review will focus on studies that shed light on the critical role of IL-1beta in various pain states, including the role of the intracellular complex, the inflammasome, which regulates IL-1beta production. Evidence will be presented demonstrating the importance of IL-1beta in both the induction of pain and in the maintenance of pain in chronic states, such as after nerve injury. Additionally, the involvement of IL-1beta as a key mediator in the interaction between glia and neurons in pain states will be discussed. Taken together, the evidence presented in the current review showing the importance of IL-1beta in animal and human pain states, suggests that blockade of IL-1beta be considered as a therapeutic opportunity.

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          Author and article information

          Journal
          Brain Research Reviews
          Brain Research Reviews
          Elsevier BV
          01650173
          April 2009
          April 2009
          : 60
          : 1
          : 57-64
          10.1016/j.brainresrev.2008.12.020
          3076185
          19166877
          © 2009

          https://www.elsevier.com/tdm/userlicense/1.0/

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