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      Convergence of Wnt,  -Catenin, and Cadherin Pathways

      Science

      American Association for the Advancement of Science (AAAS)

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          Abstract

          The specification and proper arrangements of new cell types during tissue differentiation require the coordinated regulation of gene expression and precise interactions between neighboring cells. Of the many growth factors involved in these events, Wnts are particularly interesting regulators, because a key component of their signaling pathway, beta-catenin, also functions as a component of the cadherin complex, which controls cell-cell adhesion and influences cell migration. Here, we assemble evidence of possible interrelations between Wnt and other growth factor signaling, beta-catenin functions, and cadherin-mediated adhesion.

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          Author and article information

          Journal
          Science
          Science
          American Association for the Advancement of Science (AAAS)
          0036-8075
          1095-9203
          March 05 2004
          March 05 2004
          : 303
          : 5663
          : 1483-1487
          Article
          10.1126/science.1094291
          3372896
          15001769
          © 2004

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