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      Convergence of Wnt, beta-catenin, and cadherin pathways.

      Science (New York, N.Y.)

      beta Catenin, Animals, Cadherins, metabolism, Cell Adhesion, Cell Differentiation, Cell Division, Cell Movement, Cytoskeletal Proteins, Growth Substances, Humans, Intercellular Signaling Peptides and Proteins, Neoplasms, genetics, physiopathology, Proto-Oncogene Proteins, Signal Transduction, Stem Cells, physiology, Trans-Activators, Transcription, Genetic, Wnt Proteins, Zebrafish Proteins

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          Abstract

          The specification and proper arrangements of new cell types during tissue differentiation require the coordinated regulation of gene expression and precise interactions between neighboring cells. Of the many growth factors involved in these events, Wnts are particularly interesting regulators, because a key component of their signaling pathway, beta-catenin, also functions as a component of the cadherin complex, which controls cell-cell adhesion and influences cell migration. Here, we assemble evidence of possible interrelations between Wnt and other growth factor signaling, beta-catenin functions, and cadherin-mediated adhesion.

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          Author and article information

          Journal
          15001769
          3372896
          10.1126/science.1094291

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