Traditional Chinese medicine and its active substances reduce vascular injury in diabetes via regulating autophagic activity

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Abstract

Due to its high prevalence, poor prognosis, and heavy burden on healthcare costs, diabetic vascular complications have become a significant public health issue. Currently, the molecular and pathophysiological mechanisms underlying diabetes-induced vascular complications remain incompletely understood. Autophagy, a highly conserved process of lysosomal degradation, maintains intracellular homeostasis and energy balance via removing protein aggregates, damaged organelles, and exogenous pathogens. Increasing evidence suggests that dysregulated autophagy may contribute to vascular abnormalities in various types of blood vessels, including both microvessels and large vessels, under diabetic conditions. Traditional Chinese medicine (TCM) possesses the characteristics of “multiple components, multiple targets and multiple pathways,” and its safety has been demonstrated, particularly with minimal toxicity in liver and kidney. Thus, TCM has gained increasing attention from researchers. Moreover, recent studies have indicated that Chinese herbal medicine and its active compounds can improve vascular damage in diabetes by regulating autophagy. Based on this background, this review summarizes the classification, occurrence process, and related molecular mechanisms of autophagy, with a focus on discussing the role of autophagy in diabetic vascular damage and the protective effects of TCM and its active compounds through the regulation of autophagy in diabetes. Moreover, we systematically elucidate the autophagic mechanisms by which TCM formulations, individual herbal extracts, and active compounds regulate diabetic vascular damage, thereby providing new candidate drugs for clinical treatment of vascular complications in diabetes. Therefore, further exploration of TCM and its active compounds with autophagy-regulating effects holds significant research value for achieving targeted therapeutic approaches for diabetic vascular complications.

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Author and article information

Contributors

Yankui Gao: Role: Role: Role:

Lei Zhang: Role: Role: Role:

Fei Zhang: Role: Role: Role: Role:

Rong Liu: Role: Role: Role:

Lei Liu: Role: Role: Role:

Xiaoyan Li: Role: Role: Role: Role:

Xiangdong Zhu: Role: Role:

Yonglin Liang: URI : https://loop.frontiersin.org/people/2603577/overviewRole: Role: Role:

Journal

Journal ID (nlm-ta): Front Pharmacol

Journal ID (iso-abbrev): Front Pharmacol

Journal ID (publisher-id): Front. Pharmacol.

Title: Frontiers in Pharmacology

Publisher: Frontiers Media S.A.

ISSN (Electronic): 1663-9812

Publication date (Electronic): 04 March 2024

Publication date Collection: 2024

Volume: 15

Electronic Location Identifier: 1355246

Affiliations

[1] ¹ Department of Basic Medicine , Gansu University of Traditional Chinese Medicine , Lanzhou, China

[2] ² Department of Traditional Chinese Medicine , Fujian University of Traditional Chinese Medicine , Lanzhou, China

[3] ³ Department of Traditional Chinese Medicine , Jiangxi University of Traditional Chinese Medicine , Nanchang, China

[4] ⁴ Department of Traditional Chinese Medicine , Ningxia Medical University , Yinchuan, China

Author notes

Edited by: Stalin Antony, University of Electronic Science and Technology of China, China

Reviewed by: Shihan Wang, Guang’anmen Hospital, China

Peizheng Yan, Shandong University of Traditional Chinese Medicine, China

*Correspondence: Xiangdong Zhu, zhuxiangdong33@ 123456163.com ; Yonglin Liang, 875532437@ 123456qq.com

[ † ]

These authors have contributed equally to this work

Article

Publisher ID: 1355246

DOI: 10.3389/fphar.2024.1355246

PMC ID: 10949535

PubMed ID: 38505420

SO-VID: 35a68216-a239-4f24-a55a-78076e9b71e5

License:

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

History

Date received : 13 December 2023

Date accepted : 26 February 2024

Funding

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This present study was supported by the National Natural Science Foundation of China, Grant/Award Number: 82360914, and the Gansu Provincial Department of Education Project, Grant/Award Number: 2021CYZC-03.