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      Drepmel-A Multi-Omics Melanoma Drug Repurposing Resource for Prioritizing Drug Combinations and Understanding Tumor Microenvironment.

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          Abstract

          Although substantial progress has been made in treating patients with advanced melanoma with targeted and immuno-therapies, de novo and acquired resistance is commonplace. After treatment failure, therapeutic options are very limited and novel strategies are urgently needed. Combination therapies are often more effective than single agents and are now widely used in clinical practice. Thus, there is a strong need for a comprehensive computational resource to define rational combination therapies. We developed a Shiny app, DRepMel to provide rational combination treatment predictions for melanoma patients from seventy-three thousand combinations based on a multi-omics drug repurposing computational approach using whole exome sequencing and RNA-seq data in bulk samples from two independent patient cohorts. DRepMel provides robust predictions as a resource and also identifies potential treatment effects on the tumor microenvironment (TME) using single-cell RNA-seq data from melanoma patients. Availability: DRepMel is accessible online.

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          Author and article information

          Journal
          Cells
          Cells
          MDPI AG
          2073-4409
          2073-4409
          Sep 16 2022
          : 11
          : 18
          Affiliations
          [1 ] Biostatistics and Bioinformatics Shared Resource, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
          [2 ] Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
          [3 ] Department of Dermatology and Cutaneous Surgery, University of South Florida, Tampa, FL 33612, USA.
          [4 ] Department of Cutaneous Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
          [5 ] Department of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
          Article
          cells11182894
          10.3390/cells11182894
          9497118
          36139469
          37dd474a-9041-4bd5-806c-239cfd930646
          History

          drug repurposing,melanoma,microenvironment,multi-omics
          drug repurposing, melanoma, microenvironment, multi-omics

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