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Receptor for advanced-glycation end products: key modulator of myocardial ischemic injury.
Loredana G Bucciarelli
1 ,
Michiyo Kaneko ,
Radha Ananthakrishnan ,
Evis Harja ,
Larisse K Lee ,
Yuying C Hwang ,
Shulamit Lerner ,
Soliman Bakr ,
Qing Li ,
Yan Lu ,
Fei Song ,
Wu Qu ,
Teodoro Gomez ,
Yu Shan Zou ,
Shi Fang Yan ,
Ann Marie Schmidt ,
Ravichandran Ramasamy
Mar 07 2006
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Abstract
The beneficial effects of reperfusion therapies have been limited by the amount of ischemic damage that occurs before reperfusion. To enable development of interventions to reduce cell injury, our research has focused on understanding mechanisms involved in cardiac cell death after ischemia/reperfusion (I/R) injury. In this context, our laboratory has been investigating the role of the receptor for advanced-glycation end products (RAGE) in myocardial I/R injury.