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      Considerações sobre a toxicocinética da Cannabis sativa L. ou maconha, com enfase no homem Translated title: Some aspects of pharmacokinetics of Cannabis sativa L. (Marihuana) with emphasis on man

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          Abstract

          O presente artigo consiste em uma análise sobre a origem da Cannabis no Brasil, suas principais substâncias químicas, realçando o Δ9 tetrahidrocanabinol como responsável pelos efeitos farmacológicos. é citado também o fato de existirem duas formas de numeração dos carbonos do ∆THC. Para melhor entender a toxicocinética foram feitas considerações sobre as doses de maconha, que vão variar de acordo com o usuário, e origem do vegetal. Finalmente é feito urn estudo detalhado sobre, absorção, distribuição, armazenamento, biotransformação e eliminação dos diversos componentes químicos da maconha.

          Translated abstract

          This paper contains an analysis of the origin of the introduction of Cannabis in Brazil, the identify of its chemical components, mainly tetrahydrocannabinol responsible for the pharmacological effects of Cannabis. Toxicokinetic studies were developed in relation the amounts of marihuana consumed, characteristics of the user and origin of the drug. Absorption, distribution, storage, biotransformation and elimination of marihuana derived metabolites were studies.

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          Most cited references16

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          THE IN VITRO AND IN VIVO METABOLISM OF TETRAHYDROCANNABINOL (THC)

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            METABOLISM AND DISPOSITION OF TETRAHYDROCANNABINOLS IN NÄIVE SUBJECTS AND CHRONIC MARIJUANA USERS

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              In vivo metabolites of cannabinol identified as fatty acid conjugates

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                Author and article information

                Contributors
                Role: ND
                Journal
                rbfar
                Revista Brasileira de Farmacognosia
                Rev. bras. farmacogn.
                Sociedade Brasileira de Farmacognosia (Curitiba )
                1981-528X
                1989
                : 2-3-4
                : 0
                : 88-96
                Affiliations
                [1 ] Universidade de São Paulo Brazil
                Article
                S0102-695X1989000100009
                10.1590/S0102-695X1989000100009
                388a2e09-3319-4ee9-a45c-da81266e5d5f

                http://creativecommons.org/licenses/by/4.0/

                History
                Product

                SciELO Brazil

                Self URI (journal page): http://www.scielo.br/scielo.php?script=sci_serial&pid=0102-695X&lng=en
                Categories
                PHARMACOLOGY & PHARMACY

                Pharmacology & Pharmaceutical medicine
                Cannabis sativa L.,Marihuana,Δ9THC,tetrahydocanabinol,Metabolism,Toxicology,Maconha,Biotransformação,Toxicologia

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