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      Effectiveness and Limitations of the Use of the Gonadotropin-Releasing Hormone Agonist Leuprolide Acetate in the Diagnosis of Delayed Puberty in Males

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          In order to evaluate the effectiveness of the gonadotropin-releasing hormone agonist leuprolide acetate in distinguishing gonadotropin deficiency from delayed puberty, a single subcutaneous dose of 20 μg/kg of leuprolide acetate was administered at 07.00 h to 14 patients with constitutionally delayed puberty and to 8 gonadotropin-deficient subjects, and serum gonadotropin and testosterone levels were determined at baseline and 1,2, 3, 6,12, and 24 h thereafter. The increase in gonadotropin and testosterone levels was significant in patients with delayed puberty, so that the mean peak luteinizing hormone and to a lesser degree the mean peak testosterone levels clearly differentiated normally delayed from gonadotropin-deficient puberty. However, when the peak gonadotropin and testosterone concentrations were analyzed individually, there was a considerable overlap between the two groups of males, limiting the usefulness of this test.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          10 December 2008
          : 48
          : 1
          : 1-4
          aUnidad de Endocrinologia Pediatrica, Hospital de Clinicas Caracas; bUnidad de Endocrinologia, Hospital Universitario de Los Andes; cClinica Avila y dDivision de Endocrinologia, Hospital Central ‘Dr. Carlos Arvelo’, Caracas, Venezuela
          185421 Horm Res 1997;48:1–4
          © 1997 S. Karger AG, Basel

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          Pages: 4
          Original Paper


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